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dc.contributor.authorAlmirol, Ellen A.en_US
dc.contributor.authorChi, Lisa Y.en_US
dc.contributor.authorKhurana, Bhartien_US
dc.contributor.authorHurwitz, Shelleyen_US
dc.contributor.authorBluman, Eric M.en_US
dc.contributor.authorChiodo, Christopheren_US
dc.contributor.authorMatzkin, Elizabethen_US
dc.contributor.authorBaima, Jenniferen_US
dc.contributor.authorLeBoff, Meryl S.en_US
dc.date.accessioned2017-12-06T05:50:08Z
dc.date.issued2016en_US
dc.identifier.citationAlmirol, Ellen A., Lisa Y. Chi, Bharti Khurana, Shelley Hurwitz, Eric M. Bluman, Christopher Chiodo, Elizabeth Matzkin, Jennifer Baima, and Meryl S. LeBoff. 2016. “Short-term effects of teriparatide versus placebo on bone biomarkers, structure, and fracture healing in women with lower-extremity stress fractures: A pilot study.” Journal of Clinical & Translational Endocrinology 5 (1): 7-14. doi:10.1016/j.jcte.2016.05.004. http://dx.doi.org/10.1016/j.jcte.2016.05.004.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34492158
dc.description.abstractAims In this pilot, placebo-controlled study, we evaluated whether brief administration of teriparatide (TPTD) in premenopausal women with lower-extremity stress fractures would increase markers of bone formation in advance of bone resorption, improve bone structure, and hasten fracture healing according to magnetic resonance imaging (MRI). Methods: Premenopausal women with acute lower-extremity stress fractures were randomized to injection of TPTD 20-µg subcutaneous (s.c.) (n = 6) or placebo s.c. (n = 7) for 8 weeks. Biomarkers for bone formation N-terminal propeptide of type I procollagen (P1NP) and osteocalcin (OC) and resorption collagen type-1 cross-linked C-telopeptide (CTX) and collagen type 1 cross-linked N-telopeptide (NTX) were measured at baseline, 4 and 8 weeks. The area between the percent change of P1NP and CTX over study duration is defined as the anabolic window. To assess structural changes, peripheral quantitative computed topography (pQCT) was measured at baseline, 8 and 12 weeks at the unaffected tibia and distal radius. The MRI of the affected bone assessed stress fracture healing at baseline and 8 weeks. Results: After 8 weeks of treatment, bone biomarkers P1NP and OC increased more in the TPTD- versus placebo-treated group (both p ≤ 0.01), resulting in a marked anabolic window (p ≤ 0.05). Results from pQCT demonstrated that TPTD-treated women showed a larger cortical area and thickness compared to placebo at the weight bearing tibial site, while placebo-treated women had a greater total tibia and cortical density. No changes at the radial sites were observed between groups. According to MRI, 83.3% of the TPTD- and 57.1% of the placebo-treated group had improved or healed stress fractures (p = 0.18). Conclusions: In this randomized, pilot study, brief administration of TPTD showed anabolic effects that TPTD may help hasten fracture healing in premenopausal women with lower-extremity stress fractures. Larger prospective studies are warranted to determine the effects of TPTD treatment on stress fracture healing in premenopausal women.en
dc.language.isoen_USen
dc.publisherElsevieren
dc.relation.isversionofdoi:10.1016/j.jcte.2016.05.004en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644467/pdf/en
dash.licenseLAAen_US
dc.subjectTeriparatideen
dc.subjectPilot studyen
dc.subjectPremenopausalen
dc.subjectStress fractureen
dc.subjectAnabolic windowen
dc.titleShort-term effects of teriparatide versus placebo on bone biomarkers, structure, and fracture healing in women with lower-extremity stress fractures: A pilot studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalJournal of Clinical & Translational Endocrinologyen
dash.depositing.authorKhurana, Bhartien_US
dc.date.available2017-12-06T05:50:08Z
dc.identifier.doi10.1016/j.jcte.2016.05.004*
dash.contributor.affiliatedChiodo, Christopher
dash.contributor.affiliatedKhurana, Bharti
dash.contributor.affiliatedMatzkin, Elizabeth
dash.contributor.affiliatedHurwitz, Shelley
dash.contributor.affiliatedLeboff, Meryl


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