Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy
View/ Open
Author
Zhang, Lei
Turzhitsky, Vladimir
Yee, Eric U.
Shinagare, Shweta
Vitkin, Edward
Zakharov, Yuri
Khan, Umar
Wang, Fen
Goldberg, Saveli
Itzkan, Irving
Qiu, Le
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1038/s41551-017-0040Metadata
Show full item recordCitation
Zhang, L., D. K. Pleskow, V. Turzhitsky, E. U. Yee, T. M. Berzin, M. Sawhney, S. Shinagare, et al. 2017. “Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy.” Nature biomedical engineering 1 (1): 0040. doi:10.1038/s41551-017-0040. http://dx.doi.org/10.1038/s41551-017-0040.Abstract
Pancreatic cancers are usually detected at an advanced stage and have poor prognosis. About one fifth of these arise from pancreatic cystic lesions. Yet not all lesions are precancerous, and imaging tools lack adequate accuracy for distinguishing precancerous from benign cysts. Therefore, decisions on surgical resection usually rely on endoscopic ultrasound-guided fine needle aspiration (EUS-FNA). Unfortunately, cyst fluid often contains few cells, and fluid chemical analysis lacks accuracy, resulting in dire consequences, including unnecessary pancreatic surgery for benign cysts and the development of cancer. Here, we report an optical spectroscopic technique, based on a spatial gating fibre-optic probe, that predicts the malignant potential of pancreatic cystic lesions during routine diagnostic EUS-FNA procedures. In a double-blind prospective study in 25 patients, with 14 cysts measured in vivo and 13 postoperatively, the technique achieved an overall accuracy of 95%, with a 95%confidence interval of 78–99%, in cysts with definitive diagnosis.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646377/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492235
Collections
- HMS Scholarly Articles [17922]
Contact administrator regarding this item (to report mistakes or request changes)