Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

DSpace/Manakin Repository

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

Citable link to this page

 

 
Title: Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
Author: Mathys, Hansruedi; Adaikkan, Chinnakkaruppan; Gao, Fan; Young, Jennie Z.; Manet, Elodie; Hemberg, Martin; De Jager, Philip L.; Ransohoff, Richard M.; Regev, Aviv; Tsai, Li-Huei

Note: Order does not necessarily reflect citation order of authors.

Citation: Mathys, Hansruedi, Chinnakkaruppan Adaikkan, Fan Gao, Jennie Z. Young, Elodie Manet, Martin Hemberg, Philip L. De Jager, Richard M. Ransohoff, Aviv Regev, and Li-Huei Tsai. 2017. “Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution.” Cell reports 21 (2): 366-380. doi:10.1016/j.celrep.2017.09.039. http://dx.doi.org/10.1016/j.celrep.2017.09.039.
Full Text & Related Files:
Abstract: SUMMARY Microglia, the tissue-resident macrophages in the brain, are damage sensors that react to nearly any perturbation, including neurodegenerative diseases such as Alzheimer’s disease (AD). Here, using single-cell RNA sequencing, we determined the transcriptome of more than 1,600 individual microglia cells isolated from the hippocampus of a mouse model of severe neurodegeneration with AD-like phenotypes and of control mice at multiple time points during progression of neurodegeneration. In this neurodegeneration model, we discovered two molecularly distinct reactive microglia phenotypes that are typified by modules of co-regulated type I and type II interferon response genes, respectively. Furthermore, our work identified previously unobserved heterogeneity in the response of microglia to neurodegeneration, discovered disease stage-specific microglia cell states, revealed the trajectory of cellular reprogramming of microglia in response to neurodegeneration, and uncovered the underlying transcriptional programs.
Published Version: doi:10.1016/j.celrep.2017.09.039
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642107/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492262
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters