Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6

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Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6

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Title: Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6
Author: Lee, Joo-Hyeon; Tammela, Tuomas; Hofree, Matan; Choi, Jinwook; Marjanovic, Nemanja Despot; Han, Seungmin; Canner, David; Wu, Katherine; Paschini, Margherita; Bhang, Dong Ha; Jacks, Tyler; Regev, Aviv; Kim, Carla F.

Note: Order does not necessarily reflect citation order of authors.

Citation: Lee, J., T. Tammela, M. Hofree, J. Choi, N. D. Marjanovic, S. Han, D. Canner, et al. 2017. “Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6.” Cell 170 (6): 1149-1163.e12. doi:10.1016/j.cell.2017.07.028. http://dx.doi.org/10.1016/j.cell.2017.07.028.
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Abstract: Summary The diversity of mesenchymal cell types in the lung that influence epithelial homeostasis and regeneration is poorly defined. We used genetic lineage tracing, single-cell RNA sequencing, and organoid culture approaches to show that Lgr5 and Lgr6, well-known markers of stem cells in epithelial tissues, are markers of mesenchymal cells in the adult lung. Lgr6+ cells comprise a subpopulation of smooth muscle cells surrounding airway epithelia and promote airway differentiation of epithelial progenitors via Wnt-Fgf10 cooperation. Genetic ablation of Lgr6+ cells impairs airway injury repair in vivo. Distinct Lgr5+ cells are located in alveolar compartments and are sufficient to promote alveolar differentiation of epithelial progenitors through Wnt activation. Modulating Wnt activity altered differentiation outcomes specified by mesenchymal cells. This identification of region- and lineage-specific crosstalk between epithelium and their neighboring mesenchymal partners provides new understanding of how different cell types are maintained in the adult lung.
Published Version: doi:10.1016/j.cell.2017.07.028
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607351/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492267
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