Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans

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Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans

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Title: Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans
Author: Kleckner, Ian R.; Zhang, Jiahe; Touroutoglou, Alexandra; Chanes, Lorena; Xia, Chenjie; Simmons, W. Kyle; Quigley, Karen S.; Dickerson, Bradford C.; Barrett, Lisa Feldman

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Citation: Kleckner, Ian R., Jiahe Zhang, Alexandra Touroutoglou, Lorena Chanes, Chenjie Xia, W. Kyle Simmons, Karen S. Quigley, Bradford C. Dickerson, and Lisa Feldman Barrett. 2017. “Evidence for a Large-Scale Brain System Supporting Allostasis and Interoception in Humans.” Nature human behaviour 1 (1): 0069. doi:10.1038/s41562-017-0069. http://dx.doi.org/10.1038/s41562-017-0069.
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Abstract: Large-scale intrinsic brain systems have been identified for exteroceptive senses (e.g., sight, hearing, touch). We introduce an analogous system for representing sensations from within the body, called interoception, and demonstrate its relation to regulating peripheral systems in the body, called allostasis. Employing the recently introduced Embodied Predictive Interoception Coding (EPIC) model, we used tract-tracing studies of macaque monkeys, followed by two intrinsic functional magnetic resonance imaging samples (N = 280 and N = 270) to evaluate the existence of an intrinsic allostatic/interoceptive system in the human brain. Another sample (N = 41) allowed us to evaluate the convergent validity of the hypothesized allostatic/interoceptive system by showing that individuals with stronger connectivity between system hubs performed better on an implicit index of interoceptive ability related to autonomic fluctuations. Implications include insights for the brain’s functional architecture, dissolving the artificial boundary between mind and body, and unifying mental and physical illness.
Published Version: doi:10.1038/s41562-017-0069
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624222/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492276
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