MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma

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MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma

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dc.contributor.author Li, Wende en_US
dc.contributor.author Yang, Weining en_US
dc.contributor.author Liu, Yujiao en_US
dc.contributor.author Chen, Siyu en_US
dc.contributor.author Chin, Shanmin en_US
dc.contributor.author Qi, Xiaolong en_US
dc.contributor.author Zhao, Yingchao en_US
dc.contributor.author Liu, Hao en_US
dc.contributor.author Wang, Jiasheng en_US
dc.contributor.author Mei, Xueting en_US
dc.contributor.author Huang, Peigen en_US
dc.contributor.author Xu, Donghui en_US
dc.date.accessioned 2017-12-06T05:54:03Z
dc.date.issued 2017 en_US
dc.identifier.citation Li, W., W. Yang, Y. Liu, S. Chen, S. Chin, X. Qi, Y. Zhao, et al. 2017. “MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma.” Oncotarget 8 (43): 73938-73946. doi:10.18632/oncotarget.17881. http://dx.doi.org/10.18632/oncotarget.17881. en
dc.identifier.issn en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492344
dc.description.abstract Glioblastoma multiforme is the most aggressive and common primary brain tumor, and is virtually incurable due to its therapeutic resistance to radiation and chemotherapy. Curcumin is a well-known phytochemical exhibiting antitumor activity on many human cancers including glioblastoma multiforme. Given the unique miRNA expression profiles in cancer cells compared to non-cancerous cells, we investigated whether these miRNA could be used to cancer therapy. In this report we show that miR-378, a glioblastoma multiforme down regulated miRNA, may enhance the inhibitory effect of curcumin on this cancer growth. Our results indicated that the inhibitory effect of curcumin was enhanced in miR-378-expressing stable U87 cells in vitro and in vivo, compared to control cells. MiR-378 was found to target p-p38 expression, underlying the observed phenotypic changes. Thus, we concluded that miR-378 enhances the response of glioblastoma multiforme to curcumin treatment, by targeting p38. en
dc.language.iso en_US en
dc.publisher Impact Journals LLC en
dc.relation.isversionof doi:10.18632/oncotarget.17881 en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650313/pdf/ en
dash.license LAA en_US
dc.subject miR-378 en
dc.subject glioblastoma en
dc.subject U87 en
dc.subject curcumin en
dc.title MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal Oncotarget en
dash.depositing.author Qi, Xiaolong en_US
dc.date.available 2017-12-06T05:54:03Z

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