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dc.contributor.authorLi, Wendeen_US
dc.contributor.authorYang, Weiningen_US
dc.contributor.authorLiu, Yujiaoen_US
dc.contributor.authorChen, Siyuen_US
dc.contributor.authorChin, Shanminen_US
dc.contributor.authorQi, Xiaolongen_US
dc.contributor.authorZhao, Yingchaoen_US
dc.contributor.authorLiu, Haoen_US
dc.contributor.authorWang, Jiashengen_US
dc.contributor.authorMei, Xuetingen_US
dc.contributor.authorHuang, Peigenen_US
dc.contributor.authorXu, Donghuien_US
dc.date.accessioned2017-12-06T05:54:03Z
dc.date.issued2017en_US
dc.identifier.citationLi, W., W. Yang, Y. Liu, S. Chen, S. Chin, X. Qi, Y. Zhao, et al. 2017. “MicroRNA-378 enhances inhibitory effect of curcumin on glioblastoma.” Oncotarget 8 (43): 73938-73946. doi:10.18632/oncotarget.17881. http://dx.doi.org/10.18632/oncotarget.17881.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34492344
dc.description.abstractGlioblastoma multiforme is the most aggressive and common primary brain tumor, and is virtually incurable due to its therapeutic resistance to radiation and chemotherapy. Curcumin is a well-known phytochemical exhibiting antitumor activity on many human cancers including glioblastoma multiforme. Given the unique miRNA expression profiles in cancer cells compared to non-cancerous cells, we investigated whether these miRNA could be used to cancer therapy. In this report we show that miR-378, a glioblastoma multiforme down regulated miRNA, may enhance the inhibitory effect of curcumin on this cancer growth. Our results indicated that the inhibitory effect of curcumin was enhanced in miR-378-expressing stable U87 cells in vitro and in vivo, compared to control cells. MiR-378 was found to target p-p38 expression, underlying the observed phenotypic changes. Thus, we concluded that miR-378 enhances the response of glioblastoma multiforme to curcumin treatment, by targeting p38.en
dc.language.isoen_USen
dc.publisherImpact Journals LLCen
dc.relation.isversionofdoi:10.18632/oncotarget.17881en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650313/pdf/en
dash.licenseLAAen_US
dc.subjectmiR-378en
dc.subjectglioblastomaen
dc.subjectU87en
dc.subjectcurcuminen
dc.titleMicroRNA-378 enhances inhibitory effect of curcumin on glioblastomaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalOncotargeten
dash.depositing.authorQi, Xiaolongen_US
dc.date.available2017-12-06T05:54:03Z
dc.identifier.doi10.18632/oncotarget.17881*
dash.authorsorderedfalse
dash.contributor.affiliatedQi, Xiaolong
dash.contributor.affiliatedHuang, Peigen


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