A focus on extracellular Ca2+ entry into skeletal muscle

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A focus on extracellular Ca2+ entry into skeletal muscle

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Title: A focus on extracellular Ca2+ entry into skeletal muscle
Author: Cho, Chung-Hyun; Woo, Jin Seok; Perez, Claudio F; Lee, Eun Hui

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Citation: Cho, Chung-Hyun, Jin Seok Woo, Claudio F Perez, and Eun Hui Lee. 2017. “A focus on extracellular Ca2+ entry into skeletal muscle.” Experimental & Molecular Medicine 49 (9): e378. doi:10.1038/emm.2017.208. http://dx.doi.org/10.1038/emm.2017.208.
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Abstract: The main task of skeletal muscle is contraction and relaxation for body movement and posture maintenance. During contraction and relaxation, Ca2+ in the cytosol has a critical role in activating and deactivating a series of contractile proteins. In skeletal muscle, the cytosolic Ca2+ level is mainly determined by Ca2+ movements between the cytosol and the sarcoplasmic reticulum. The importance of Ca2+ entry from extracellular spaces to the cytosol has gained significant attention over the past decade. Store-operated Ca2+ entry with a low amplitude and relatively slow kinetics is a main extracellular Ca2+ entryway into skeletal muscle. Herein, recent studies on extracellular Ca2+ entry into skeletal muscle are reviewed along with descriptions of the proteins that are related to extracellular Ca2+ entry and their influences on skeletal muscle function and disease.
Published Version: doi:10.1038/emm.2017.208
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628281/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492393
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