A focus on extracellular Ca2+ entry into skeletal muscle

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A focus on extracellular Ca2+ entry into skeletal muscle

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dc.contributor.author Cho, Chung-Hyun en_US
dc.contributor.author Woo, Jin Seok en_US
dc.contributor.author Perez, Claudio F en_US
dc.contributor.author Lee, Eun Hui en_US
dc.date.accessioned 2017-12-06T05:55:03Z
dc.date.issued 2017 en_US
dc.identifier.citation Cho, Chung-Hyun, Jin Seok Woo, Claudio F Perez, and Eun Hui Lee. 2017. “A focus on extracellular Ca2+ entry into skeletal muscle.” Experimental & Molecular Medicine 49 (9): e378. doi:10.1038/emm.2017.208. http://dx.doi.org/10.1038/emm.2017.208. en
dc.identifier.issn en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492393
dc.description.abstract The main task of skeletal muscle is contraction and relaxation for body movement and posture maintenance. During contraction and relaxation, Ca2+ in the cytosol has a critical role in activating and deactivating a series of contractile proteins. In skeletal muscle, the cytosolic Ca2+ level is mainly determined by Ca2+ movements between the cytosol and the sarcoplasmic reticulum. The importance of Ca2+ entry from extracellular spaces to the cytosol has gained significant attention over the past decade. Store-operated Ca2+ entry with a low amplitude and relatively slow kinetics is a main extracellular Ca2+ entryway into skeletal muscle. Herein, recent studies on extracellular Ca2+ entry into skeletal muscle are reviewed along with descriptions of the proteins that are related to extracellular Ca2+ entry and their influences on skeletal muscle function and disease. en
dc.language.iso en_US en
dc.publisher Nature Publishing Group en
dc.relation.isversionof doi:10.1038/emm.2017.208 en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628281/pdf/ en
dash.license LAA en_US
dc.title A focus on extracellular Ca2+ entry into skeletal muscle en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal Experimental & Molecular Medicine en
dash.depositing.author Perez, Claudio F en_US
dc.date.available 2017-12-06T05:55:03Z

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