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dc.contributor.authorSheill, Gráinneen_US
dc.contributor.authorBrady, Laurenen_US
dc.contributor.authorGuinan, Emeren_US
dc.contributor.authorHayes, Brianen_US
dc.contributor.authorCasey, Orlaen_US
dc.contributor.authorGreene, Johnen_US
dc.contributor.authorVlajnic, Tatjanaen_US
dc.contributor.authorCahill, Fidelmaen_US
dc.contributor.authorVan Hemelrijck, Miekeen_US
dc.contributor.authorPeat, Nicolaen_US
dc.contributor.authorRudman, Sarahen_US
dc.contributor.authorHussey, Julietteen_US
dc.contributor.authorCunningham, Moyaen_US
dc.contributor.authorGrogan, Liamen_US
dc.contributor.authorLynch, Thomasen_US
dc.contributor.authorManecksha, Rustom P.en_US
dc.contributor.authorMcCaffrey, Johnen_US
dc.contributor.authorMucci, Loreleien_US
dc.contributor.authorSheils, Orlaen_US
dc.contributor.authorO’Leary, Johnen_US
dc.contributor.authorO’Donnell, Dearbhaile M.en_US
dc.contributor.authorMcDermott, Rayen_US
dc.contributor.authorFinn, Stephenen_US
dc.date.accessioned2017-12-06T05:57:08Z
dc.date.issued2017en_US
dc.identifier.citationSheill, G., L. Brady, E. Guinan, B. Hayes, O. Casey, J. Greene, T. Vlajnic, et al. 2017. “The ExPeCT (Examining Exercise, Prostate Cancer and Circulating Tumour Cells) trial: study protocol for a randomised controlled trial.” Trials 18 (1): 456. doi:10.1186/s13063-017-2201-3. http://dx.doi.org/10.1186/s13063-017-2201-3.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34492475
dc.description.abstractBackground: Prostate cancer (PrCa) is the second most common cancer in Ireland. Many men present with locally advanced or metastatic cancer for whom curative surgery is inappropriate. Advanced cancer patients are encouraged to remain physically active and therefore there is a need to investigate how patients with metastatic disease tolerate physical activity programmes. Physical activity reduces levels of systemic inflammatory mediators and so an aerobic exercise intervention may represent an accessible and cost-effective means of ameliorating the pro-inflammatory effects of obesity and subsequently decrease poor cancer-specific outcomes in this patient population. This study will assess the feasibility and safety of introducing a structured aerobic exercise intervention to an advanced cancer population. This study will also examine if the evasion of immune editing by circulating tumour cells (CTCs) is an exercise-modifiable mechanism in obese men with prostate cancer. Methods: This international multicentre prospective study will recruit men with metastatic prostate cancer. Participants will be recruited from centres in Dublin (Ireland) and London (UK). Participants will be divided into exposed and non-exposed groups based on body mass index (BMI) ≥ 25 kg/m2 and randomised to intervention and control groups. The exercise group will undertake a regular supervised aerobic exercise programme, whereas the control group will not. Exercise intensity will be prescribed based on a target heart rate monitored by a polar heart rate monitor. Blood samples will be taken at recruitment and at 3 and 6 months to examine the primary endpoint of platelet cloaking of CTCs. Participants will complete a detailed questionnaire to assess quality of life (QoL) and other parameters at each visit. Discussion The overall aim of the ExPeCT trial is to examine the relationship between PrCa, exercise, obesity, and systemic inflammation, and to improve the overall QoL in men with advanced disease. Results will inform future work in this area examining biological markers of prognosis in advanced prostate cancer. Trial registration Clinicaltrials.gov NLM identifier: NCT02453139. Registered on 12 May 2015. This document contains excerpts from the ExPeCT trial protocol Version 1.5, 28 July 2016.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/s13063-017-2201-3en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628461/pdf/en
dash.licenseLAAen_US
dc.subjectExerciseen
dc.subjectAdvanced canceren
dc.subjectMetastaticen
dc.subjectProstateen
dc.subjectCirculating tumour cellsen
dc.titleThe ExPeCT (Examining Exercise, Prostate Cancer and Circulating Tumour Cells) trial: study protocol for a randomised controlled trialen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalTrialsen
dash.depositing.authorMucci, Loreleien_US
dc.date.available2017-12-06T05:57:08Z
dc.identifier.doi10.1186/s13063-017-2201-3*
dash.authorsorderedfalse
dash.contributor.affiliatedMucci, Lorelei


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