Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection

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Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection

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Title: Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection
Author: Huang, Hailiang; Duggal, Priya; Thio, Chloe L.; Latanich, Rachel; Goedert, James J.; Mangia, Alessandra; Cox, Andrea L.; Kirk, Gregory D.; Mehta, Shruti; Aneja, Jasneet; Alric, Laurent; Donfield, Sharyne M.; Cramp, Matthew E.; Khakoo, Salim I.; Tobler, Leslie H.; Busch, Michael; Alexander, Graeme J.; Rosen, Hugo R.; Edlin, Brian R.; Segal, Florencia P.; Lauer, Georg M.; Thomas, David L.; Daly, Mark J.; Chung, Raymond T.; Kim, Arthur Y.

Note: Order does not necessarily reflect citation order of authors.

Citation: Huang, H., P. Duggal, C. L. Thio, R. Latanich, J. J. Goedert, A. Mangia, A. L. Cox, et al. 2017. “Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection.” Scientific Reports 7 (1): 15843. doi:10.1038/s41598-017-16011-2. http://dx.doi.org/10.1038/s41598-017-16011-2.
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Abstract: Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe.
Published Version: doi:10.1038/s41598-017-16011-2
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696522/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34493056
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