dc.contributor.author | Huang, Hailiang | en_US |
dc.contributor.author | Duggal, Priya | en_US |
dc.contributor.author | Thio, Chloe L. | en_US |
dc.contributor.author | Latanich, Rachel | en_US |
dc.contributor.author | Goedert, James J. | en_US |
dc.contributor.author | Mangia, Alessandra | en_US |
dc.contributor.author | Cox, Andrea L. | en_US |
dc.contributor.author | Kirk, Gregory D. | en_US |
dc.contributor.author | Mehta, Shruti | en_US |
dc.contributor.author | Aneja, Jasneet | en_US |
dc.contributor.author | Alric, Laurent | en_US |
dc.contributor.author | Donfield, Sharyne M. | en_US |
dc.contributor.author | Cramp, Matthew E. | en_US |
dc.contributor.author | Khakoo, Salim I. | en_US |
dc.contributor.author | Tobler, Leslie H. | en_US |
dc.contributor.author | Busch, Michael | en_US |
dc.contributor.author | Alexander, Graeme J. | en_US |
dc.contributor.author | Rosen, Hugo R. | en_US |
dc.contributor.author | Edlin, Brian R. | en_US |
dc.contributor.author | Segal, Florencia P. | en_US |
dc.contributor.author | Lauer, Georg M. | en_US |
dc.contributor.author | Thomas, David L. | en_US |
dc.contributor.author | Daly, Mark J. | en_US |
dc.contributor.author | Chung, Raymond T. | en_US |
dc.contributor.author | Kim, Arthur Y. | en_US |
dc.date.accessioned | 2017-12-06T16:17:51Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Huang, H., P. Duggal, C. L. Thio, R. Latanich, J. J. Goedert, A. Mangia, A. L. Cox, et al. 2017. “Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection.” Scientific Reports 7 (1): 15843. doi:10.1038/s41598-017-16011-2. http://dx.doi.org/10.1038/s41598-017-16011-2. | en |
dc.identifier.issn | | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:34493056 | |
dc.description.abstract | Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe. | en |
dc.language.iso | en_US | en |
dc.publisher | Nature Publishing Group UK | en |
dc.relation.isversionof | doi:10.1038/s41598-017-16011-2 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696522/pdf/ | en |
dash.license | LAA | en_US |
dc.title | Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Scientific Reports | en |
dash.depositing.author | Huang, Hailiang | en_US |
dc.date.available | 2017-12-06T16:17:51Z | |
dc.identifier.doi | 10.1038/s41598-017-16011-2 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Chung, Raymond | |
dash.contributor.affiliated | Kim, Arthur | |
dash.contributor.affiliated | Lauer, Georg | |
dash.contributor.affiliated | Huang, Hailiang | |
dash.contributor.affiliated | Daly, Mark | |