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dc.contributor.authorTam, Joshuaen_US
dc.contributor.authorWang, Yingen_US
dc.contributor.authorVuong, Linh N.en_US
dc.contributor.authorFisher, Jeremy M.en_US
dc.contributor.authorFarinelli, William A.en_US
dc.contributor.authorAnderson, R. Roxen_US
dc.date.accessioned2017-12-06T16:17:55Z
dc.date.issued2016en_US
dc.identifier.citationTam, Joshua, Ying Wang, Linh N. Vuong, Jeremy M. Fisher, William A. Farinelli, and R. Rox Anderson. 2016. “Reconstitution of full‐thickness skin by microcolumn grafting.” Journal of Tissue Engineering and Regenerative Medicine 11 (10): 2796-2805. doi:10.1002/term.2174. http://dx.doi.org/10.1002/term.2174.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34493059
dc.description.abstractAbstract In addition to providing a physical barrier, skin also serves a diverse range of physiological functions through different specialized resident cell types/structures, including melanocytes (pigmentation and protection against ultraviolet radiation), Langerhans cells (adaptive immunity), fibroblasts (maintaining extracellular matrix, paracrine regulation of keratinocytes), sweat glands (thermoregulation) and hair follicles (hair growth, sensation and a stem cell reservoir). Restoration of these functional elements has been a long‐standing challenge in efforts to engineer skin tissue, while autologous skin grafting is limited by the scarcity of donor site skin and morbidity caused by skin harvesting. We demonstrate an alternative approach of harvesting and then implanting μm‐scale, full‐thickness columns of human skin tissue, which can be removed from a donor site with minimal morbidity and no scarring. Fresh human skin microcolumns were used to reconstitute skin in wounds on immunodeficient mice. The restored skin recapitulated many key features of normal human skin tissue, including epidermal architecture, diverse skin cell populations, adnexal structures and sweat production in response to cholinergic stimulation. These promising preclinical results suggest that harvesting and grafting of microcolumns may be useful for reconstituting fully functional skin in human wounds, without donor site morbidity. © 2016 The Authors Journal of Tissue Engineering and Regenerative Medicine Published by John Wiley & Sons Ltd.en
dc.language.isoen_USen
dc.publisherJohn Wiley and Sons Inc.en
dc.relation.isversionofdoi:10.1002/term.2174en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697650/pdf/en
dash.licenseLAAen_US
dc.subjectskin wounden
dc.subjectfull thicknessen
dc.subjectadnexaen
dc.subjecthealingen
dc.subjectregenerationen
dc.titleReconstitution of full‐thickness skin by microcolumn graftingen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalJournal of Tissue Engineering and Regenerative Medicineen
dash.depositing.authorTam, Joshuaen_US
dc.date.available2017-12-06T16:17:55Z
dc.identifier.doi10.1002/term.2174*
dash.contributor.affiliatedTam, Joshua


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