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dc.contributor.authorSofer, Tamaren_US
dc.contributor.authorBaier, Leslie J.en_US
dc.contributor.authorBrowning, Sharon R.en_US
dc.contributor.authorThornton, Timothy A.en_US
dc.contributor.authorTalavera, Gregory A.en_US
dc.contributor.authorWassertheil-Smoller, Sylviaen_US
dc.contributor.authorDaviglus, Martha L.en_US
dc.contributor.authorHanson, Roberten_US
dc.contributor.authorKobes, Sayukoen_US
dc.contributor.authorCooper, Richard S.en_US
dc.contributor.authorCai, Jianwenen_US
dc.contributor.authorLevy, Danielen_US
dc.contributor.authorReiner, Alex P.en_US
dc.contributor.authorFranceschini, Noraen_US
dc.date.accessioned2017-12-06T16:18:24Z
dc.date.issued2017en_US
dc.identifier.citationSofer, T., L. J. Baier, S. R. Browning, T. A. Thornton, G. A. Talavera, S. Wassertheil-Smoller, M. L. Daviglus, et al. 2017. “Admixture mapping in the Hispanic Community Health Study/Study of Latinos reveals regions of genetic associations with blood pressure traits.” PLoS ONE 12 (11): e0188400. doi:10.1371/journal.pone.0188400. http://dx.doi.org/10.1371/journal.pone.0188400.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34493082
dc.description.abstractAdmixture mapping can be used to detect genetic association regions in admixed populations, such as Hispanics/Latinos, by estimating associations between local ancestry allele counts and the trait of interest. We performed admixture mapping of the blood pressure traits systolic and diastolic blood pressure (SBP, DBP), mean arterial pressure (MAP), and pulse pressure (PP), in a dataset of 12,116 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Hispanics/Latinos have three predominant ancestral populations (European, African, and Amerindian), for each of which we separately tested local ancestry intervals across the genome. We identified four regions that were significantly associated with a blood pressure trait at the genome-wide admixture mapping level. A 6p21.31 Amerindian ancestry association region has multiple known associations, but none explained the admixture mapping signal. We identified variants that completely explained this signal. One of these variants had p-values of 0.02 (MAP) and 0.04 (SBP) in replication testing in Pima Indians. A 11q13.4 Amerindian ancestry association region spans a variant that was previously reported (p-value = 0.001) in a targeted association study of Blood Pressure (BP) traits and variants in the vitamin D pathway. There was no replication evidence supporting an association in the identified 17q25.3 Amerindian ancestry association region. For a region on 6p12.3, associated with African ancestry, we did not identify any candidate variants driving the association. It may be driven by rare variants. Whole genome sequence data may be necessary to fine map these association signals, which may contribute to disparities in BP traits between diverse populations.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0188400en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695820/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectComputational Biologyen
dc.subjectGenome Analysisen
dc.subjectGenome-Wide Association Studiesen
dc.subjectGeneticsen
dc.subjectGenomicsen
dc.subjectHuman Geneticsen
dc.subjectMolecular Biologyen
dc.subjectMolecular Biology Techniquesen
dc.subjectGene Mappingen
dc.subjectChromosome Mappingen
dc.subjectGene Identification and Analysisen
dc.subjectMedicine and Health Sciencesen
dc.subjectVascular Medicineen
dc.subjectBlood Pressureen
dc.subjectPeople and placesen
dc.subjectPopulation groupingsen
dc.subjectEthnicitiesen
dc.subjectLatin American peopleen
dc.subjectMexican Peopleen
dc.subjectHeredityen
dc.subjectGenetic Mappingen
dc.subjectVariant Genotypesen
dc.subjectCell Biologyen
dc.subjectSignal Transductionen
dc.subjectCell Signalingen
dc.subjectGenomic Signal Processingen
dc.titleAdmixture mapping in the Hispanic Community Health Study/Study of Latinos reveals regions of genetic associations with blood pressure traitsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorSofer, Tamaren_US
dc.date.available2017-12-06T16:18:24Z
dc.identifier.doi10.1371/journal.pone.0188400*
dash.authorsorderedfalse
dash.contributor.affiliatedSofer, Tamar


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