Use of the Controlled Adverse Environment (CAE) in Clinical Research: A Review

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Use of the Controlled Adverse Environment (CAE) in Clinical Research: A Review

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Title: Use of the Controlled Adverse Environment (CAE) in Clinical Research: A Review
Author: Ousler, George W.; Rimmer, David; Smith, Lisa M.; Abelson, Mark B.

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Citation: Ousler, George W., David Rimmer, Lisa M. Smith, and Mark B. Abelson. 2017. “Use of the Controlled Adverse Environment (CAE) in Clinical Research: A Review.” Ophthalmology and Therapy 6 (2): 263-276. doi:10.1007/s40123-017-0110-x. http://dx.doi.org/10.1007/s40123-017-0110-x.
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Abstract: The many internal and external factors that contribute to the pathophysiology of dry eye disease (DED) create a difficult milieu for its study and complicate its clinical diagnosis and treatment. The controlled adverse environment (CAE®) model has been developed to minimize the variability that arises from exogenous factors and to exacerbate the signs and symptoms of DED by stressing the ocular surface in a safe, standardized, controlled, and reproducible manner. By integrating sensitive, specific, and clinically relevant endpoints, the CAE has proven to be a unique and adaptable model for both identifying study-specific patient populations with modifiable signs and symptoms, and for tailoring the evaluation of interventions in clinical research studies.
Published Version: doi:10.1007/s40123-017-0110-x
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693827/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34493184
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