Height associated variants demonstrate assortative mating in human populations

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Height associated variants demonstrate assortative mating in human populations

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Title: Height associated variants demonstrate assortative mating in human populations
Author: Li, Xiaoyin; Redline, Susan; Zhang, Xiang; Williams, Scott; Zhu, Xiaofeng

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Citation: Li, Xiaoyin, Susan Redline, Xiang Zhang, Scott Williams, and Xiaofeng Zhu. 2017. “Height associated variants demonstrate assortative mating in human populations.” Scientific Reports 7 (1): 15689. doi:10.1038/s41598-017-15864-x. http://dx.doi.org/10.1038/s41598-017-15864-x.
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Abstract: Understanding human mating patterns, which can affect population genetic structure, is important for correctly modeling populations and performing genetic association studies. Prior studies of assortative mating in humans focused on trait similarity among spouses and relatives via phenotypic correlations. Limited research has quantified the genetic consequences of assortative mating. The degree to which the non-random mating influences genetic architecture remains unclear. Here, we studied genetic variants associated with human height to assess the degree of height-related assortative mating in European-American and African-American populations. We compared the inbreeding coefficient estimated using known height associated variants with that calculated from frequency matched sets of random variants. We observed significantly higher inbreeding coefficients for the height associated variants than from frequency matched random variants (P < 0.05), demonstrating height-related assortative mating in both populations.
Published Version: doi:10.1038/s41598-017-15864-x
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691191/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34493238
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