Phagocytosis imprints heterogeneity in tissue-resident macrophages

DSpace/Manakin Repository

Phagocytosis imprints heterogeneity in tissue-resident macrophages

Citable link to this page

 

 
Title: Phagocytosis imprints heterogeneity in tissue-resident macrophages
Author: A-Gonzalez, Noelia; Quintana, Juan A.; García-Silva, Susana; Mazariegos, Marina; González de la Aleja, Arturo; Nicolás-Ávila, José A.; Walter, Wencke; Adrover, Jose M.; Crainiciuc, Georgiana; Kuchroo, Vijay K.; Rothlin, Carla V.; Peinado, Héctor; Castrillo, Antonio; Ricote, Mercedes; Hidalgo, Andrés

Note: Order does not necessarily reflect citation order of authors.

Citation: A-Gonzalez, N., J. A. Quintana, S. García-Silva, M. Mazariegos, A. González de la Aleja, J. A. Nicolás-Ávila, W. Walter, et al. 2017. “Phagocytosis imprints heterogeneity in tissue-resident macrophages.” The Journal of Experimental Medicine 214 (5): 1281-1296. doi:10.1084/jem.20161375. http://dx.doi.org/10.1084/jem.20161375.
Full Text & Related Files:
Abstract: Tissue-resident macrophages display varying phenotypic and functional properties that are largely specified by their local environment. One of these functions, phagocytosis, mediates the natural disposal of billions of cells, but its mechanisms and consequences within living tissues are poorly defined. Using a parabiosis-based strategy, we identified and isolated macrophages from multiple tissues as they phagocytosed blood-borne cellular material. Phagocytosis was circadianally regulated and mediated by distinct repertoires of receptors, opsonins, and transcription factors in macrophages from each tissue. Although the tissue of residence defined the core signature of macrophages, phagocytosis imprinted a distinct antiinflammatory profile. Phagocytic macrophages expressed CD206, displayed blunted expression of Il1b, and supported tissue homeostasis. Thus, phagocytosis is a source of macrophage heterogeneity that acts together with tissue-derived factors to preserve homeostasis.
Published Version: doi:10.1084/jem.20161375
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413334/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34493300
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters