Very Late Antigen 1 Blockade Markedly Promotes Survival of Corneal Allografts
R. de Fougerolles, Antonin
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CitationChen, Lu. 2007. “Very Late Antigen 1 Blockade Markedly Promotes Survival of Corneal Allografts.” Archives of Ophthalmology 125 (6) (June 1): 783. doi:10.1001/archopht.125.6.783.
To investigate the role of very late antigen 1 (VLA-1) (also known as integrin receptor α1β1) in corneal transplantation inflammation and allograft survival.
Cell infiltration and vasculogenesis (both angiogenesis and lymphangiogenesis) associated with allodisparate corneal transplantation were assessed in VLA-1—deficient conditions and controls by immunofluorescent microscopic studies. Corneal allograft survival was also assessed after anti—VLA-1 antibody treatment and in VLA-1 knockout recipient mice.
Anti—VLA-1 antibody treatment leads to a profound reduction in the granulocytic, monocytic, and T-cell infiltration after corneal transplantation. In addition, corneal angiogenesis and lymphangiogenesis were both significantly suppressed in VLA-1 knockout mice. Remarkably, universal graft survival was observed in both anti—VLA-1 antibody treatment and knockout mice.
Very late antigen 1 blockade markedly reduces inflammation and inflammation-induced tissue responses, including vasculogenic responses, associated with corneal transplantation and promotes allograft survival.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34622453
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