Time to Drug-Resistant Tuberculosis Treatment in a Prospective South African Cohort

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Time to Drug-Resistant Tuberculosis Treatment in a Prospective South African Cohort

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Title: Time to Drug-Resistant Tuberculosis Treatment in a Prospective South African Cohort
Author: van de Water, Brittney J.; Prvu Bettger, Janet; Silva, Susan; Humphreys, Janice; Cunningham, Coleen K.; Farley, Jason E.

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Citation: van de Water, Brittney J., Janet Prvu Bettger, Susan Silva, Janice Humphreys, Coleen K. Cunningham, and Jason E. Farley. 2017. “Time to Drug-Resistant Tuberculosis Treatment in a Prospective South African Cohort.” Global Pediatric Health 4 (1): 2333794X17744140. doi:10.1177/2333794X17744140. http://dx.doi.org/10.1177/2333794X17744140.
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Abstract: This study examined time to treatment initiation by age among a prospective cohort with drug-resistant tuberculosis (DR-TB). Participants aged 13 years or older nested within a cluster-randomized trial in 2 South African provinces were evaluated. Outcomes were treatment initiation within 5 days of DR-TB diagnosis (National Tuberculosis Program guidelines) and days from diagnosis to treatment. A total of 521 participants met inclusion criteria. Eighty-two patients (16%) met national guidelines; median time to treatment was 11 days (range = 0-180). No patient (age, sex, prior TB history, HIV status) or health system characteristics (geographic urban/rural location, province) were associated with treatment initiation per guidelines except geographic location (t = 3.64, degrees of freedom = 1, P = .0003). One in 6 individuals with DR-TB received treatment per guidelines, and average time to treatment was 11 days. Strategies are needed to decrease treatment delays and meet the recommended guidelines for treatment for patients of all ages.
Published Version: doi:10.1177/2333794X17744140
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714082/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34651813
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