A Sub-millimeter, Inductively Powered Neural Stimulator

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A Sub-millimeter, Inductively Powered Neural Stimulator

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Title: A Sub-millimeter, Inductively Powered Neural Stimulator
Author: Freeman, Daniel K.; O'Brien, Jonathan M.; Kumar, Parshant; Daniels, Brian; Irion, Reed A.; Shraytah, Louis; Ingersoll, Brett K.; Magyar, Andrew P.; Czarnecki, Andrew; Wheeler, Jesse; Coppeta, Jonathan R.; Abban, Michael P.; Gatzke, Ronald; Fried, Shelley I.; Lee, Seung Woo; Duwel, Amy E.; Bernstein, Jonathan J.; Widge, Alik S.; Hernandez-Reynoso, Ana; Kanneganti, Aswini; Romero-Ortega, Mario I.; Cogan, Stuart F.

Note: Order does not necessarily reflect citation order of authors.

Citation: Freeman, D. K., J. M. O'Brien, P. Kumar, B. Daniels, R. A. Irion, L. Shraytah, B. K. Ingersoll, et al. 2017. “A Sub-millimeter, Inductively Powered Neural Stimulator.” Frontiers in Neuroscience 11 (1): 659. doi:10.3389/fnins.2017.00659. http://dx.doi.org/10.3389/fnins.2017.00659.
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Abstract: Wireless neural stimulators are being developed to address problems associated with traditional lead-based implants. However, designing wireless stimulators on the sub-millimeter scale (<1 mm3) is challenging. As device size shrinks, it becomes difficult to deliver sufficient wireless power to operate the device. Here, we present a sub-millimeter, inductively powered neural stimulator consisting only of a coil to receive power, a capacitor to tune the resonant frequency of the receiver, and a diode to rectify the radio-frequency signal to produce neural excitation. By replacing any complex receiver circuitry with a simple rectifier, we have reduced the required voltage levels that are needed to operate the device from 0.5 to 1 V (e.g., for CMOS) to ~0.25–0.5 V. This reduced voltage allows the use of smaller receive antennas for power, resulting in a device volume of 0.3–0.5 mm3. The device was encapsulated in epoxy, and successfully passed accelerated lifetime tests in 80°C saline for 2 weeks. We demonstrate a basic proof-of-concept using stimulation with tens of microamps of current delivered to the sciatic nerve in rat to produce a motor response.
Published Version: doi:10.3389/fnins.2017.00659
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712043/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34651861
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