Hippocampal oxytocin receptors are necessary for discrimination of social stimuli

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Hippocampal oxytocin receptors are necessary for discrimination of social stimuli

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Title: Hippocampal oxytocin receptors are necessary for discrimination of social stimuli
Author: Raam, Tara; McAvoy, Kathleen M.; Besnard, Antoine; Veenema, Alexa; Sahay, Amar

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Citation: Raam, Tara, Kathleen M. McAvoy, Antoine Besnard, Alexa Veenema, and Amar Sahay. 2017. “Hippocampal oxytocin receptors are necessary for discrimination of social stimuli.” Nature Communications 8 (1): 2001. doi:10.1038/s41467-017-02173-0. http://dx.doi.org/10.1038/s41467-017-02173-0.
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Abstract: Oxytocin receptor (Oxtr) signaling in neural circuits mediating discrimination of social stimuli and affiliation or avoidance behavior is thought to guide social recognition. Remarkably, the physiological functions of Oxtrs in the hippocampus are not known. Here we demonstrate using genetic and pharmacological approaches that Oxtrs in the anterior dentate gyrus (aDG) and anterior CA2/CA3 (aCA2/CA3) of mice are necessary for discrimination of social, but not non-social, stimuli. Further, Oxtrs in aCA2/CA3 neurons recruit a population-based coding mechanism to mediate social stimuli discrimination. Optogenetic terminal-specific attenuation revealed a critical role for aCA2/CA3 outputs to posterior CA1 for discrimination of social stimuli. In contrast, aCA2/CA3 projections to aCA1 mediate discrimination of non-social stimuli. These studies identify a role for an aDG-CA2/CA3 axis of Oxtr expressing cells in discrimination of social stimuli and delineate a pathway relaying social memory computations in the anterior hippocampus to the posterior hippocampus to guide social recognition.
Published Version: doi:10.1038/s41467-017-02173-0
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722862/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34651992
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