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dc.contributor.authorTan, Longzhi
dc.contributor.authorZong, Chenghang
dc.contributor.authorXie, Xiaoliang Sunney
dc.date.accessioned2018-01-23T19:01:26Z
dc.date.issued2013
dc.identifierQuick submit: 2013-12-18T14:01:20-05:00
dc.identifier.citationTan, L., C. Zong, and X. S. Xie. 2013. “Rare Event of Histone Demethylation Can Initiate Singular Gene Expression of Olfactory Receptors.” Proceedings of the National Academy of Sciences 110 (52) (December 24): 21148–21152. doi:10.1073/pnas.1321511111.en_US
dc.identifier.issn1091-6490en_US
dc.identifier.issn1091-6490en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34721989
dc.description.abstractIn mammals, the sense of odors relies on the peculiar expression pattern of olfactory receptors (ORs). Each single neuron chooses one, and only one, from all ∼1,400 OR genes that are present in a mouse genome. In neurobiology, a long-standing mystery is how such singularity can be achieved. We show theoretically that a simple kinetic scheme of OR activation followed by feedback can be solely responsible for the observed singularity, as long as the two timescales—slow activation by epigenetic modification and fast feedback by transcriptional regulation—are well separated. Our work provides the theoretical underpinning behind the choice of ORs, and demonstrates how the nervous system utilizes the kinetics of epigenetic changes to direct neurogenesis.en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.language.isoen_USen_US
dc.publisherProceedings of the National Academy of Sciencesen_US
dc.relation.isversionofdoi:10.1073/pnas.1321511111en_US
dash.licenseMETA_ONLY
dc.subjectneurogenesisen_US
dc.subjectstochastic gene expressionen_US
dc.subjecthistone modificationen_US
dc.subjectkinetics modelingen_US
dc.subjectnegative feedbacken_US
dc.titleRare event of histone demethylation can initiate singular gene expression of olfactory receptorsen_US
dc.typeJournal Articleen_US
dc.date.updated2013-12-18T19:02:41Z
dc.description.versionAccepted Manuscripten_US
dc.rights.holderLongzhi Tan, Chenghang Zong, Xiaoliang Sunney Xie
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dash.depositing.authorXie, Xiaoliang Sunney
dash.embargo.until10000-01-01
dc.identifier.doi10.1073/pnas.1321511111*
workflow.legacycommentsoap.needmanen_US
dash.contributor.affiliatedTan, Longzhi
dash.contributor.affiliatedZong, Chenghang
dash.contributor.affiliatedXie, Xiaoliang


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