A Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern

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A Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern

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dc.contributor.author Hoekstra, Hopi E.
dc.date.accessioned 2018-01-24T17:42:01Z
dc.date.issued 2006
dc.identifier Quick submit: 2014-07-12T11:54:59-04:00
dc.identifier.citation Hoekstra, H. E. 2006. A Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern. Science 313, no. 5783: 101–104. doi:10.1126/science.1126121. en_US
dc.identifier.issn 0036-8075 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:34728590
dc.description.abstract Natural populations of beach mice exhibit a characteristic color pattern, relative to their mainland conspecifics, driven by natural selection for crypsis. We identified a derived, charge-changing amino acid mutation in the melanocortin-1 receptor (Mc1r) in beach mice, which decreases receptor function. In genetic crosses, allelic variation at Mc1r explains 9.8% to 36.4% of the variation in seven pigmentation traits determining color pattern. The derived Mc1r allele is present in Florida's Gulf Coast beach mice but not in Atlantic coast mice with similar light coloration, suggesting that different molecular mechanisms are responsible for convergent phenotypic evolution. Here, we link a single mutation in the coding region of a pigmentation gene to adaptive quantitative variation in the wild. en_US
dc.description.sponsorship Organismic and Evolutionary Biology en_US
dc.language.iso en_US en_US
dc.publisher American Association for the Advancement of Science (AAAS) en_US
dc.relation.isversionof doi:10.1126/science.1126121 en_US
dash.license META_ONLY
dc.title A Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern en_US
dc.type Journal Article en_US
dc.date.updated 2014-07-12T15:55:00Z
dc.description.version Version of Record en_US
dc.rights.holder Hoekstra, H.E., Hirschmann, R.J., Bundey, R.J., Insel, P. and J.P. Crossland
dc.relation.journal Science en_US
dash.depositing.author Hoekstra, Hopi E.
dash.embargo.until 10000-01-01

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