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dc.contributor.authorHoekstra, Hopi E.
dc.date.accessioned2018-01-24T17:42:01Z
dc.date.issued2006
dc.identifierQuick submit: 2014-07-12T11:54:59-04:00
dc.identifier.citationHoekstra, H. E. 2006. A Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Pattern. Science 313, no. 5783: 101–104. doi:10.1126/science.1126121.en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34728590
dc.description.abstractNatural populations of beach mice exhibit a characteristic color pattern, relative to their mainland conspecifics, driven by natural selection for crypsis. We identified a derived, charge-changing amino acid mutation in the melanocortin-1 receptor (Mc1r) in beach mice, which decreases receptor function. In genetic crosses, allelic variation at Mc1r explains 9.8% to 36.4% of the variation in seven pigmentation traits determining color pattern. The derived Mc1r allele is present in Florida's Gulf Coast beach mice but not in Atlantic coast mice with similar light coloration, suggesting that different molecular mechanisms are responsible for convergent phenotypic evolution. Here, we link a single mutation in the coding region of a pigmentation gene to adaptive quantitative variation in the wild.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherAmerican Association for the Advancement of Science (AAAS)en_US
dc.relation.isversionofdoi:10.1126/science.1126121en_US
dash.licenseMETA_ONLY
dc.titleA Single Amino Acid Mutation Contributes to Adaptive Beach Mouse Color Patternen_US
dc.typeJournal Articleen_US
dc.date.updated2014-07-12T15:55:00Z
dc.description.versionVersion of Recorden_US
dc.rights.holderHoekstra, H.E., Hirschmann, R.J., Bundey, R.J., Insel, P. and J.P. Crossland
dc.relation.journalScienceen_US
dash.depositing.authorHoekstra, Hopi E.
dash.embargo.until10000-01-01
dc.identifier.doi10.1126/science.1126121*
workflow.legacycommentsnoap.needman (MM) Hoekstra emailed 2016-05-15 MM Hoekstra emailed 2017-03-02 MMen_US
dash.contributor.affiliatedHoekstra, Hopi


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