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dc.contributor.authorKarlsson, Elinor Kathryn
dc.contributor.authorKwiatkowski, Dominic P.
dc.contributor.authorSabeti, Pardis Christine
dc.date.accessioned2018-01-24T17:56:38Z
dc.date.issued2014
dc.identifierQuick submit: 2014-09-03T16:18:59-04:00
dc.identifier.citationKarlsson, Elinor K., Dominic P. Kwiatkowski, and Pardis C. Sabeti. 2014. “Natural Selection and Infectious Disease in Human Populations.” Nature Reviews Genetics 15 (6) (April 29): 379–393. doi:10.1038/nrg3734.en_US
dc.identifier.issn1471-0056en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34728612
dc.description.abstractThe ancient biological 'arms race' between microbial pathogens and humans has shaped genetic variation in modern populations, and this has important implications for the growing field of medical genomics. As humans migrated throughout the world, populations encountered distinct pathogens, and natural selection increased the prevalence of alleles that are advantageous in the new ecosystems in both host and pathogens. This ancient history now influences human infectious disease susceptibility and microbiome homeostasis, and contributes to common diseases that show geographical disparities, such as autoimmune and metabolic disorders. Using new high-throughput technologies, analytical methods and expanding public data resources, the investigation of natural selection is leading to new insights into the function and dysfunction of human biology.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isversionofdoi:10.1038/nrg3734en_US
dash.licenseMETA_ONLY
dc.subjectGenetics of infectious disease resistanceen_US
dc.subjectInfectious disease selection and common diseaseen_US
dc.titleNatural selection and infectious disease in human populationsen_US
dc.typeJournal Articleen_US
dc.date.updated2014-09-03T20:18:59Z
dc.description.versionVersion of Recorden_US
dc.rights.holderElinor K. Karlsson, Dominic P. Kwiatkowski, and Pardis C. Sabeti
dc.relation.journalNature Reviews Geneticsen_US
dash.depositing.authorKarlsson, Elinor Kathryn
dash.embargo.until10000-01-01
dc.identifier.doi10.1038/nrg3734*
dash.contributor.affiliatedKarlsson, Elinor K
dash.contributor.affiliatedSabeti, Pardis


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