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dc.contributor.authorGrossman, Shamai Aaron
dc.contributor.authorAndersen, Kristian G
dc.contributor.authorShlyakhter, Ilya
dc.contributor.authorTabrizi, Shervin
dc.contributor.authorWinnicki, Sarah M.
dc.contributor.authorYen, Angela
dc.contributor.authorPark, Daniel J.
dc.contributor.authorGriesemer, Dustin Shahab
dc.contributor.authorKarlsson, Elinor Kathryn
dc.contributor.authorWong, Sunny H.
dc.contributor.authorCabili, Moran
dc.contributor.authorAdegbola, Richard A.
dc.contributor.authorBamezai, Rameshwar N.K.
dc.contributor.authorHill, Adrian V.S.
dc.contributor.authorVannberg, Fredrik O.
dc.contributor.authorRinn, John L
dc.contributor.authorLander, Eric Steven
dc.contributor.authorSchaffner, Stephen
dc.contributor.authorSabeti, Pardis Christine
dc.date.accessioned2018-01-24T17:57:13Z
dc.date.issued2013
dc.identifierQuick submit: 2014-09-03T15:56:43-04:00
dc.identifier.citationGrossman, Sharon R., Kristian G. Andersen, Ilya Shlyakhter, Shervin Tabrizi, Sarah Winnicki, Angela Yen, Daniel J. Park, et al. 2013. “Identifying Recent Adaptations in Large-Scale Genomic Data.” Cell 152 (4) (February): 703–713. doi:10.1016/j.cell.2013.01.035.en_US
dc.identifier.issn0092-8674en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34728613
dc.description.abstractSummary: Although several hundred regions of the human genome harbor signals of positive natural selection, few of the relevant adaptive traits and variants have been elucidated. Using full-genome sequence variation from the 1000 Genomes (1000G) Project and the composite of multiple signals (CMS) test, we investigated 412 candidate signals and leveraged functional annotation, protein structure modeling, epigenetics, and association studies to identify and extensively annotate candidate causal variants. The resulting catalog provides a tractable list for experimental follow-up; it includes 35 high-scoring nonsynonymous variants, 59 variants associated with expression levels of a nearby coding gene or lincRNA, and numerous variants associated with susceptibility to infectious disease and other phenotypes. We experimentally characterized one candidate nonsynonymous variant in Toll-like receptor 5 (TLR5) and show that it leads to altered NF-κB signaling in response to bacterial flagellin.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.cell.2013.01.035en_US
dash.licenseMETA_ONLY
dc.titleIdentifying Recent Adaptations in Large-Scale Genomic Dataen_US
dc.typeJournal Articleen_US
dc.date.updated2014-09-03T19:56:44Z
dc.description.versionVersion of Recorden_US
dc.rights.holderSharon R. Grossman, Kristian G. Andersen, Ilya Shlyakhter, Shervin Tabrizi, Sarah Winnicki, Angela Yen, Daniel J. Park, Dustin Griesemer, Elinor K. Karlsson, Sunny H. Wong, Moran Cabili, Richard A. Adegbola, Rameshwar N. K. Bemezai, Adrian V. S. Hill, Fredrik O. Vannberg, John L. Rinn, 1000 Genomes Project, Eric S. Lander, Stephen F. Schaffner, and Pardis C. Sabeti
dc.relation.journalCellen_US
dash.depositing.authorAndersen, Kristian G
dash.embargo.until10000-01-01
dc.identifier.doi10.1016/j.cell.2013.01.035*
workflow.legacycommentsnoap.needman (MM)en_US
dash.authorsorderedfalse
dash.contributor.affiliatedGrossman, Shamai
dash.contributor.affiliatedGriesemer, Dustin
dash.contributor.affiliatedWinnicki, Sarah
dash.contributor.affiliatedShlyakhter, Ilya
dash.contributor.affiliatedSchaffner, Stephen
dash.contributor.affiliatedAndersen, Kristian G
dash.contributor.affiliatedKarlsson, Elinor K
dash.contributor.affiliatedSabeti, Pardis
dash.contributor.affiliatedRinn, John
dash.contributor.affiliatedLander, Eric


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