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dc.contributor.authorBezerra, Hiram Grando
dc.contributor.authorHiguchi, Maria de Lourdes
dc.contributor.authorGutierrez, Paulo Sampaio
dc.contributor.authorPalomino, Sueli Aparecida
dc.contributor.authorSilvestre, Julia Maria La Chioma
dc.contributor.authorLibby, Peter
dc.contributor.authorRamires, José Antonio Franchini
dc.date.accessioned2018-01-24T18:02:57Z
dc.date.issued2001
dc.identifier.citationBezerra, Hiram Grando, Maria de Lourdes Higuchi, Paulo Sampaio Gutierrez, Sueli Aparecida Palomino, Julia Maria La Chioma Silvestre, Peter Libby, and José Antonio Franchini Ramires. 2001. “Atheromas That Cause Fatal Thrombosis Are Usually Large and Frequently Accompanied by Vessel Enlargement.” Cardiovascular Pathology 10 (4) (July): 189–196. doi:10.1016/s1054-8807(01)00070-9.en_US
dc.identifier.issn1054-8807en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34728623
dc.description.abstractSeveral lines of clinical evidence show that AMI frequently occurs at sites with mild to moderate degree of coronary stenosis. The degree of luminal stenosis depends on plaque deposition and degree of vessel remodeling, features poorly assessed by coronary angiography. This postmortem study tested the hypothesis that the size of coronary atheroma and the type of remodeling distinguish culprit lesion responsible for fatal AMI from equi-stenotic nonculprit lesion in the same coronary tree. The main coronary branches from 36 consecutive patients with fatal AMI were studied. The culprit lesion (Group 1) and an equi-stenotic nonculprit segment (Group 2) obtained in measurements of another coronary branch from the same patient were compared. Morphometry and plaque composition was assessed in both groups. Compared to Group 2, Group 1 had larger areas of: plaque \(9.6 vs. 4.7 mm^2\), vessel \(12.7 vs. 7.4 mm^2\) and lumen \(1.7 vs. 1.2 mm^2\); (P<.01). Positive remodeling was more frequent in Group 1 than Group 2: 21/30 (70%) vs. 8/26 (31%). Plaque area correlated positively with lipid core and macrophages and negatively with fibrosis and smooth muscle cells. Atherosclerotic plaques that cause fatal thrombosis are more frequently positively remodeled and tend to be larger than nonculprit plaques with the same degree of cross-sectional stenosis. We tested whether arterial remodeling and plaque size vary between segments containing a fatal thrombosed plaque versus an equi-stenotic nonculprit plaque. Culprit vessel segments had higher cross-sectional areas of intimal plaque and of vessel wall than equi-stenotic nonculprit plaques. The cross-sectional area of the vessel correlated positively with both the lipid core area and \(CD68^+\) macrophage content, and negatively with fibrosis area and smooth muscle cell content. These results add elements explaining limitations of angiography in identifying plaques and provide new insights into the role of remodeling in plaque instability.en_US
dc.description.sponsorshipOther Research Uniten_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/S1054-8807(01)00070-9en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pubmed/11600336en_US
dash.licenseMETA_ONLY
dc.subjectAtherosclerosisen_US
dc.subjectRemodelingen_US
dc.subjectPlaqueen_US
dc.subjectMyocardial infarctionen_US
dc.subjectPathologyen_US
dc.titleAtheromas that cause fatal thrombosis are usually large and frequently accompanied by vessel enlargementen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalCardiovascular Pathologyen_US
dash.depositing.authorLibby, Peter
dash.embargo.until10000-01-01
dc.identifier.doi10.1016/S1054-8807(01)00070-9*
workflow.legacycommentsauth.collection Move to HMS. noap.needman (MM)en_US
dash.contributor.affiliatedLibby, Peter
dc.identifier.orcid0000-0002-1502-502X


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