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dc.contributor.authorGrosberg, Anna
dc.contributor.authorAlford, Patrick W.
dc.contributor.authorMcCain, Megan L.
dc.contributor.authorParker, Kevin Kit
dc.date.accessioned2018-01-24T18:24:57Z
dc.date.issued2011
dc.identifier.citationGrosberg, Anna, Patrick W. Alford, Megan L. McCain, and Kevin Kit Parker. 2011. “Ensembles of Engineered Cardiac Tissues for Physiological and Pharmacological Study: Heart on a Chip.” Lab on a Chip 11 (24): 4165. doi:10.1039/c1lc20557a.en_US
dc.identifier.issn1473-0197en_US
dc.identifier.issn1473-0189en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34728639
dc.description.abstractTraditionally, muscle physiology experiments require multiple tissue samples to obtain morphometric, electrophysiological, and contractility data. Furthermore, these experiments are commonly completed one at a time on cover slips of single cells, isotropic monolayers, or in isolated muscle strips. In all of these cases, variability of the samples hinders quantitative comparisons among experimental groups. Here, we report the design of a “heart on a chip” that exploits muscular thin film technology – biohybrid constructs of an engineered, anisotropic ventricular myocardium on an elastomeric thin film – to measure contractility, combined with a quantification of action potential propagation, and cytoskeletal architecture in multiple tissues in the same experiment. We report techniques for real-time data collection and analysis during pharmacological intervention. The chip is an efficient means of measuring structure-function relationships in constructs that replicate the hierarchical tissue architectures of laminar cardiac muscle.en_US
dc.description.sponsorshipEngineering and Applied Sciencesen_US
dc.language.isoen_USen_US
dc.publisherRoyal Society of Chemistry (RSC)en_US
dc.relation.isversionofdoi:10.1039/c1lc20557aen_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pubmed/22072288en_US
dash.licenseMETA_ONLY
dc.titleEnsembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chipen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalLab on a Chipen_US
dash.depositing.authorParker, Kevin Kit
dash.embargo.until10000-01-01
dc.identifier.doi10.1039/c1lc20557a*
workflow.legacycommentsoap.needmanen_US
dash.contributor.affiliatedParker, Kevin


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