Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development

DSpace/Manakin Repository

Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development

Citable link to this page

 

 
Title: Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development
Author: Azim, Eiman; Shnider, Sara J.; Cederquist, Gustav Y.; Sohur, Usharbudh Shivraj; Macklis, Jeffrey Daniel

Note: Order does not necessarily reflect citation order of authors.

Citation: Azim, E., S. J. Shnider, G. Y. Cederquist, U. S. Sohur, and J. D. Macklis. 2009. Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development. Cerebral Cortex 19, suppl. 1: i62–i69. doi:10.1093/cercor/bhp030.
Access Status: Full text of the requested work is not available in DASH at this time (“dark deposit”). For more information on dark deposits, see our FAQ.
Full Text & Related Files:
Abstract: Molecular controls over the development of the exceptional neuronal subtype diversity of the cerebral cortex are now beginning to be identified. The initial subtype fate decision early in the life of a neuron, and the malleability of this fate when the balance of key postmitotic signals is modified, reveals not only that a neuron is deterministically set on a general developmental path at its birth, but also that this program must be precisely executed during postmitotic differentiation. Here, we show that callosal projection neurons (CPN) and subcerebral projection neurons (subcerebral PN) in layer V of the neocortex share aspects of molecular identity after their birth that are progressively resolved during differentiation. The LIM-homeodomain-related genes Lmo4 and Clim1 are initially expressed by both CPN and subcerebral PN in layer V, and only during mid to late differentiation does expression of Lmo4 and Clim1 become largely segregated into distinct neuronal subtypes. This progressive postmitotic resolution of molecular identity reveals similarities and possibly shared evolutionary origin between layer V CPN and subcerebral PN, and provides insight into how and when these neuronal subtypes achieve their distinct identities during cortical development.
Published Version: 10.1093/cercor/bhp030
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34730532
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters