Show simple item record

dc.contributor.authorHeo, Muyoung
dc.contributor.authorKang, Louis
dc.contributor.authorShakhnovich, Eugene Isaacovitch
dc.date.accessioned2018-01-24T21:18:19Z
dc.date.issued2009
dc.identifierQuick submit: 2017-05-15T21:39:54-0400
dc.identifier.citationHeo, Muyoung, Louis Kang, and Eugene I. Shakhnovich. 2009. “Emergence of Species in Evolutionary ‘simulated Annealing.’” Proceedings of the National Academy of Sciences 106 (6) (January 22): 1869–1874. doi:10.1073/pnas.0809852106.en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34736495
dc.description.abstractWhich factors govern the evolution of mutation rates and emergence of species? Here, we address this question by using a first principles model of life where population dynamics of asexual organisms is coupled to molecular properties and interactions of proteins encoded in their genomes. Simulating evolution of populations, we found that fitness increases in punctuated steps via epistatic events, leading to formation of stable and functionally interacting proteins. At low mutation rates, species form populations of organisms tightly localized in sequence space, whereas at higher mutation rates, species are lost without an apparent loss of fitness. However, when mutation rate was a selectable trait, the population initially maintained high mutation rate until a high fitness level was reached, after which organisms with low mutation rates are gradually selected, with the population eventually reaching mutation rates comparable with those of modern DNAbased organisms. This study shows that the fitness landscape of a biophysically realistic system is extremely complex, with huge number of local peaks rendering adaptation dynamics to be a glass-like process. On a more practical level, our results provide a rationale to experimental observations of the effect of mutation rate on fitness of populations of asexual organisms.en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.language.isoen_USen_US
dc.publisherProceedings of the National Academy of Sciencesen_US
dc.relation.isversionofdoi:10.1073/pnas.0809852106en_US
dash.licenseMETA_ONLY
dc.subjectdigital lifeen_US
dc.subjectfitness landscapeen_US
dc.subjectmolecular evolutionen_US
dc.subjectmutation ratesen_US
dc.subjectprotein interaction networksen_US
dc.titleEmergence of species in evolutionary “simulated annealing”en_US
dc.typeJournal Articleen_US
dc.date.updated2017-05-16T01:39:12Z
dc.description.versionVersion of Recorden_US
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dash.depositing.authorShakhnovich, Eugene Isaacovitch
dash.embargo.until10000-01-01
dc.date.available2009
dc.identifier.doi10.1073/pnas.0809852106*
workflow.legacycommentsoap.needmanen_US
dash.contributor.affiliatedHeo, Muyoung
dash.contributor.affiliatedShakhnovich, Eugene


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record