Antibody response to booster vaccination with tetanus and diphtheria in adults exposed to perfluorinated alkylates

DSpace/Manakin Repository

Antibody response to booster vaccination with tetanus and diphtheria in adults exposed to perfluorinated alkylates

Citable link to this page

 

 
Title: Antibody response to booster vaccination with tetanus and diphtheria in adults exposed to perfluorinated alkylates
Author: Kielsen, Katrine; Shamim, Zaiba; Ryder, Lars P.; Nielsen, Flemming; Grandjean, Philippe; Budtz-Jørgensen, Esben; Heilmann, Carsten

Note: Order does not necessarily reflect citation order of authors.

Citation: Kielsen, Katrine, Zaiba Shamim, Lars P. Ryder, Flemming Nielsen, Philippe Grandjean, Esben Budtz-Jørgensen, and Carsten Heilmann. 2015. “Antibody Response to Booster Vaccination with Tetanus and Diphtheria in Adults Exposed to Perfluorinated Alkylates.” Journal of Immunotoxicology 13 (2) (July 16): 270–273. doi:10.3109/1547691x.2015.1067259.
Full Text & Related Files:
Abstract: Recent studies suggest that exposure to perfluorinated alkylate substances (PFASs) may induce immunosuppression in humans and animal models. In this exploratory study, twelve healthy adult volunteers were recruited. With each subject, serum-PFAS concentrations were measured and their antibody responses prospectively followed for 30 days after a booster vaccination with diphtheria and tetanus. The results indicated that serum-PFAS concentrations were positively correlated, and positively associated, with age and male sex. The specific antibody concentrations in serum were increased from Day 4 to Day 10 post-booster, after which a constant concentration was reached. Serum PFAS concentrations showed significant negative associations with the rate of increase in the antibody responses. Interestingly, this effect was particularly strong for the longer-chain PFASs. All significant associations remained significant after adjustment for sex and age. Although the study involved a small number of subjects, these findings of a PFAS-associated reduction of the early humoral immune response to booster vaccination in healthy adults supported previous findings of PFAS immunosuppression in larger cohorts. Furthermore, the results suggested to us that cellular mechanisms right after antigen exposure should be investigated more closely to identify possible mechanisms of immunosuppression from PFAS.
Published Version: doi:10.3109/1547691X.2015.1067259
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739630/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34767887
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters