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dc.contributor.authorWhite, Roberta F
dc.contributor.authorPalumbo, Carole L.
dc.contributor.authorYurgelun-Todd, Deborah
dc.contributor.authorHeaton, Kristin J.
dc.contributor.authorWeihe, Pal
dc.contributor.authorDebes, Frodi
dc.contributor.authorGrandjean, Philippe
dc.date.accessioned2018-02-01T22:08:49Z
dc.date.issued2011
dc.identifier.citationWhite, Roberta F., Carole L. Palumbo, Deborah A. Yurgelun-Todd, Kristin J. Heaton, Pal Weihe, Frodi Debes, and Philippe Grandjean. 2011. “Functional MRI Approach to Developmental Methylmercury and Polychlorinated Biphenyl Neurotoxicity.” NeuroToxicology 32 (6) (December): 975–980. doi:10.1016/j.neuro.2011.04.001.en_US
dc.identifier.issn0161-813Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34767899
dc.description.abstractPrenatal and early childhood exposure to methylmercury (MeHg) or polychlorinated biphenyls (PCBs) are associated with deficits in cognitive, sensory, motor and other functions measured by neurobehavioral tests. The main objective of this pilot study was to determine whether functional magnetic resonance imaging (fMRI) is effective for visualization of brain function alterations related to neurobehavior in subjects with high prenatal exposure to the two neurotoxicants, MeHg and PCBs. Twelve adolescents (all boys) from a Faroese birth cohort assembled in 1986–1987 were recruited based on their prenatal exposures to MeHg and PCB. All underwent fMRI scanning during behavioral tasks at age 15 years. Subjects with high mixed exposure to MeHg and PCBs were compared to those with low mixed exposure on fMRI photic stimulation and a motor task. Boys with low mixed exposures showed patterns of fMRI activation during visual and motor tasks that are typical of normal control subjects. However, those with high exposures showed activation in more areas of the brain and different and wider patterns of activation than the low mixed exposure group. The brain activation patterns observed in association with increased exposures to MeHg and PCBs are meaningful in regard to the known neurotoxicity of these substances. This methodology therefore has potential utility in visualizing structural neural system determinants of exposure-induced neurobehavioral dysfunction.en_US
dc.language.isoen_USen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofdoi:10.1016/j.neuro.2011.04.001en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410805/en_US
dash.licenseLAA
dc.subjectDevelopmental neurotoxicityen_US
dc.subjectEnvironmental exposureen_US
dc.subjectFunctional magnetic resonance imagingen_US
dc.subjectMethylmercuryen_US
dc.subjectNeurotoxicity syndromesen_US
dc.subjectPolychlorinated biphenylsen_US
dc.subjectPrenatal exposure delayed effectsen_US
dc.titleFunctional MRI approach to developmental methylmercury and polychlorinated biphenyl neurotoxicityen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalNeuroToxicologyen_US
dash.depositing.authorGrandjean, Philippe
dc.date.available2018-02-01T22:08:49Z
dc.identifier.doi10.1016/j.neuro.2011.04.001*
dash.contributor.affiliatedYurgelun-Todd, Deborah
dash.contributor.affiliatedWhite, Roberta
dash.contributor.affiliatedWeihe, Pal
dash.contributor.affiliatedGrandjean, Philippe
dc.identifier.orcid0000-0003-4046-9658


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