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dc.contributor.authorGrandjean, Philippe
dc.contributor.authorWeihe, Pal
dc.contributor.authorNielsen, JB
dc.date.accessioned2018-02-02T21:36:51Z
dc.date.issued1994
dc.identifierQuick submit: 2017-09-21T13:34:20-0400
dc.identifier.citationGrandjean P, Weihe P, Nielsen JB. 1994. Methylmercury: significance of intrauterine and postnatal exposures.. Clinical Chemistry 40 (7 - pt. 2): 1395-1400.en_US
dc.identifier.issn0009-9147en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34776470
dc.description.abstractOutbreaks of methylmercury poisoning in Japan and Iraq have demonstrated the sensitivity of the fetus to neurotoxic effects. Based on toxicokinetics and considerations of practicability, the optimal biomarker of methylmercury exposure is the hair concentration, but whole-blood measurements of mercury are also useful. Dose-response relations are still incompletely known, especially concerning developmental neurotoxicity under conditions of chronic exposure. Available evidence indicates that neurobehavioral dysfunction in children may occur if the maternal mercury concentration in hair is >6 pg/g (30 nmol/g). This value corresponds to a blood mercury concentration of -24 pgIL (120 nmol/L). The period of maximum sensitivity of the nervous system to methylmercury toxicity is unknown, but the transfer of mercury to the newborn through human milk may represent an additional risk. In view of the wide occurrence of mercury contamination in developing countries, increased use of the exposure biomarkers is encouraged.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Association for Clinical Chemistryen_US
dash.licenseMETA_ONLY
dc.titleMethylmercury: significance of intrauterine and postnatal exposures.en_US
dc.typeJournal Articleen_US
dc.date.updated2017-09-21T17:34:22Z
dc.description.versionVersion of Recorden_US
dc.relation.journalClinical Chemistryen_US
dash.depositing.authorGrandjean, Philippe
dash.embargo.until10000-01-01
dc.date.available1994
dash.contributor.affiliatedWeihe, Pal
dash.contributor.affiliatedGrandjean, Philippe
dc.identifier.orcid0000-0003-4046-9658


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