Biomarkers of chemical exposure: state of the art.
View/ Open
Biomarkers_of_Chemical_Exposure-_State_of_the_Art.pdf (717.9Kb)
Access Status
Full text of the requested work is not available in DASH at this time ("dark deposit"). For more information on dark deposits, see our FAQ.Published Version
http://clinchem.aaccjnls.org/content/40/7/1360Metadata
Show full item recordCitation
Grandjean P, Brown SS, Reavey P, Young DS. 1994. Biomarkers of chemical exposure: state of the art.. Clinical Chemistry 40 (7): 1363Abstract
Establishing associations between environmental agents and disease presents challenges to both epidemiologists and toxicologists, particularly in cases of complex gene-environment interactions and when there is a long latency between exposure and disease. Biologic markers, physiological signals that reflect exposure, early cellular response, or inherent or acquired susceptibilities, provide a new strategy for resolving some of these problems. Biomarker research assumes that toxicant-induced diseases are progressive and that injury proceeds from entry of the toxicant into target cells, which induces subcellular biochemical events, to cell- and organ-level events that eventually induce irreversible or persistent organism dysfunction. The epidemiologic value of a biomarker lies in its ability to predict backward toward exposure and forward toward risk of clinical outcome, which is largely unknown. Research in mechanistic toxicology will advance the range of useful biomarkers in epidemiology and clinical medicine.Citable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:34776471
Collections
- SPH Scholarly Articles [6344]
Contact administrator regarding this item (to report mistakes or request changes)