No changes in lymphocyte muscarinic receptors and platelet monoamine oxidase-B examined as surrogate central nervous system biomarkers in a Faroese children cohort prenatally exposed to methylmercury and polychlorinated biphenyls

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No changes in lymphocyte muscarinic receptors and platelet monoamine oxidase-B examined as surrogate central nervous system biomarkers in a Faroese children cohort prenatally exposed to methylmercury and polychlorinated biphenyls

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Title: No changes in lymphocyte muscarinic receptors and platelet monoamine oxidase-B examined as surrogate central nervous system biomarkers in a Faroese children cohort prenatally exposed to methylmercury and polychlorinated biphenyls
Author: Coccini, Teresa; Manzo, Luigi; Debes, Frodi; Steuerwald, Ulrike; Weihe, Pal; Grandjean, Philippe

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Citation: Coccini, Teresa, Luigi Manzo, Frodi Debes, Ulrike Steuerwald, Pál Weihe, and Philippe Grandjean. 2009. “No Changes in Lymphocyte Muscarinic Receptors and Platelet Monoamine Oxidase-B Examined as Surrogate Central Nervous System Biomarkers in a Faroese Children Cohort Prenatally Exposed to Methylmercury and Polychlorinated Biphenyls.” Biomarkers 14 (2) (March): 67–76. doi:10.1080/13547500902783739.
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Abstract: Experimental evidence suggests that monoamine oxidase B (MAO-B) and muscarinic cholinergic receptors (mAChRs) are involved in the pathogenesis of neurotoxicity caused by methylmercury and polychlorinated biphenyls (PCBs). Blood samples from 7-year-old exposed children were analyzed for platelet MAO-B and lymphocyte mAChRs as potential markers of exposure to these neurotoxicants. The blood neurotoxicity biomarkers were compared with prenatal and current exposures and with neuropsychological test results. Both biomarkers showed homogeneous distributions within this cohort (mAChR, range 0.04–36.78 fmol/million cells; MAO-B, 0.95–14.95 nmol mg−1 protein h−1). No correlation was found between the two biomarkers and either blood neurotoxicant concentrations or clinical findings. MAO-B and mAChR sensitivity may not be sufficiently high to assess early, subclinical responses to low/moderate methylmercury and/or PCB exposure, whereas these markers are significantly altered in sustained exposure scenarios, as shown by clinical studies in drug addicts or patients treated with psychopharmacological agents.
Published Version: doi:10.1080/13547500902783739
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415987/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34786425
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