Effects of Exposure Imprecision on Estimation of the Benchmark Dose

DSpace/Manakin Repository

Effects of Exposure Imprecision on Estimation of the Benchmark Dose

Citable link to this page

 

 
Title: Effects of Exposure Imprecision on Estimation of the Benchmark Dose
Author: Budtz-Jorgensen, Esben; Keiding, Niels; Grandjean, Philippe

Note: Order does not necessarily reflect citation order of authors.

Citation: Budtz-Jorgensen, Esben, Niels Keiding, and Philippe Grandjean. 2004. “Effects of Exposure Imprecision on Estimation of the Benchmark Dose.” Risk Analysis 24 (6) (December): 1689–1696. doi:10.1111/j.0272-4332.2004.00560.x.
Full Text & Related Files:
Abstract: In regression analysis failure to adjust for imprecision in the exposure variable is likely to lead to underestimation of the exposure effect. However, the consequences of exposure error for determination of safe doses of toxic substances have so far not received much attention. The benchmark approach is one of the most widely used methods for development of exposure limits. An important advantage of this approach is that it can be applied to observational data. However, in this type of data, exposure markers are seldom measured without error. It is shown that, if the exposure error is ignored, then the benchmark approach produces results that are biased toward higher and less protective levels. It is therefore important to take exposure measurement error into account when calculating benchmark doses. Methods that allow this adjustment are described and illustrated in data from an epidemiological study on the health effects of prenatal mercury exposure.
Published Version: doi:10.1111/j.0272-4332.2004.00560.x
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34786615
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters