Benchmark dose calculations of methylmercury-associated neurobehavioural deficits
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CitationBudtz-Jørgensen, Esben, Philippe Grandjean, Niels Keiding, Roberta F. White, and Pal Weihe. 2000. “Benchmark Dose Calculations of Methylmercury-Associated Neurobehavioural Deficits.” Toxicology Letters 112-113 (March): 193–199. doi:10.1016/s0378-4274(99)00283-0.
AbstractPrenatal methylmercury exposure is associated with neuropsychological deficits in Faroese children at age 7 years. Lower confidence bounds of benchmark doses (BMDLs) have now been calculated. With the cord-blood mercury concentration as the dose parameter, a logarithmic dose-response model tended to show a better fit than a linear dose model for the attention, language and verbal memory tests. The lowest BMDLs averaged ≈5 μg/l cord blood, which corresponds to a maternal hair concentration of ≈1 μg/g. However, most BMDLs for hair mercury concentrations were higher. Thus, the results of the benchmark calculations depend on the assumed dose-response model.
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