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dc.contributor.authorAmparo, Francisco
dc.contributor.authorWang, Haobing
dc.contributor.authorEmami-Naeini, Parisa
dc.contributor.authorKarimian, Parisa
dc.contributor.authorDana, Reza
dc.date.accessioned2018-02-08T20:18:05Z
dc.date.issued2013
dc.identifierQuick submit: 2017-06-18T21:14:33-0400
dc.identifier.citationAmparo, Francisco, Haobing Wang, Parisa Emami-Naeini, Parisa Karimian, and Reza Dana. 2013. “The Ocular Redness Index: A Novel Automated Method for Measuring Ocular Injection.” Investigative Opthalmology & Visual Science 54 (7) (July 18): 4821. doi:10.1167/iovs.13-12217.en_US
dc.identifier.issn1552-5783en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34814008
dc.description.abstractPurpose. To develop and validate a novel automated system to assess ocular redness (OR) in clinical images. Methods. We developed a novel software that quantifies OR in digital images based on a mathematic algorithm using a centesimal continuous scoring scale. Subsequently, we conducted a study to validate the scores obtained with this system by correlating them with those obtained by two physicians using two image-based comparative subjective scales, the Efron and the Validated Bulbar Redness (VBR) grading scales. Additionally, we evaluated the level of clinical agreement between the Ocular Redness Index (ORI) score and the two image-based methods by means of the Bland-Altman analysis. Main outcome measures included correlation and level of agreement between the ORI score, Efron score, and the VBR score. Results. One hundred and two clinical photographs of eyes with OR were evaluated. The ORI scores significantly correlated with the scores obtained by the two clinicians using the Efron (Observer 1, R = 0.925, P < 0.001; Observer 2, R = 0.857, P < 0.001), and VBR (Observer 1, R = 0.830, P < 0.001; Observer 2, R = 0.821, P < 0.001) scales. The Bland-Altman analysis revealed levels of disagreement of up to 30 and 27 units for the ORI–Efron and ORI–VBR score comparisons, respectively. Conclusions. The ORI provides an objective and continuous scale for evaluating ocular injection in an automated manner, and without need for a trained physician for scoring. The ORI may be used as a new alternative for objective OR evaluation in clinics and in clinical trials.en_US
dc.language.isoen_USen_US
dc.publisherAssociation for Research in Vision and Ophthalmology (ARVO)en_US
dc.relation.isversionof10.1167/iovs.13-12217en_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720148/en_US
dash.licenseLAA
dc.subjectocular rednessen_US
dc.subjectconjunctival injectionen_US
dc.subjectocular surfaceen_US
dc.subjectocular symptomsen_US
dc.titleThe Ocular Redness Index: A Novel Automated Method for Measuring Ocular Injectionen_US
dc.typeJournal Articleen_US
dc.date.updated2017-06-19T01:14:35Z
dc.description.versionVersion of Recorden_US
dc.relation.journalInvestigative Opthalmology & Visual Scienceen_US
dash.depositing.authorDana, Reza
dc.date.available2013
dc.date.available2018-02-08T20:18:05Z
dc.identifier.doi10.1167/iovs.13-12217*
workflow.legacycommentscat.completeen_US
dash.contributor.affiliatedWang, Haobing
dash.contributor.affiliatedDana, Reza


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