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dc.contributor.authorSaboo, Ujwala S.
dc.contributor.authorAmparo, Francisco
dc.contributor.authorShikari, Hasanain
dc.contributor.authorDana, Reza
dc.date.accessioned2018-02-23T20:31:37Z
dc.date.issued2016
dc.identifierQuick submit: 2017-06-18T21:56:01-0400
dc.identifier.citationSaboo, Ujwala S., Francisco Amparo, Hasanain Shikari, and Reza Dana. 2016. “Prevalence of Ocular Hypertension and Glaucoma in Patients with Chronic Ocular Graft-Versus-Host Disease.” Graefe’s Archive for Clinical and Experimental Ophthalmology 254 (5) (March 12): 923–928. doi:10.1007/s00417-016-3312-3.en_US
dc.identifier.issn1552-5783en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34865261
dc.description.abstractPurpose: To compare densities of corneal epithelial dendritic cells (DCs), corneal subbasal nerves, and conjunctival epithelial immune cells (EICs) between patients with dry eye disease (DED) with and without graft-versus-host disease (GVHD) using in vivo confocal microscopy (IVCM). Methods: This study included 54 patients who had moderate to severe DED either associated with (n = 33) or without (n = 21) chronic GVHD. In addition to evaluating clinical parameters of DED, images obtained by laser-scanning IVCM of the central cornea and superior tarsal conjunctiva were analyzed to measure densities of corneal epithelial DCs, corneal subbasal nerves, and conjunctival EICs. Results: Although there were no significant differences between GVHD and non-GVHD groups in symptom scores, the GVHD group had significantly worse corneal fluorescein staining, tear break-up time, and Schirmer's scores than the non-GVHD group. Corneal epithelial DC density, corneal subbasal nerve density, and conjunctival EIC density were 148 ± 135 cells/mm2, 16.3 ± 6.1 mm/mm2, and 670 ± 267 cells/mm2, respectively, in the GVHD group; and 122 ± 99 cells/mm2, 18.3 ± 5.1 mm/mm2, and 572 ± 271 cells/mm2, respectively, in the non-GVHD group. After adjusting for clinical parameters, including the DED severity, none of the IVCM parameters was significantly different between the GVHD versus non-GVHD groups (P = 0.82, P = 0.21, and P = 0.60, respectively). Conclusions: In GVHD-associated DED, cellular changes in the cornea and conjunctiva observed by IVCM were similar to those seen in patients who have non-GVHD dry eye with the same level of disease severity. Therefore, corneal and conjunctival IVCM findings in GVHD-associated DED are possibly reflective of the local disease (DED) severity rather than the underlying systemic disease process.en_US
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.hasversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842331/en_US
dash.licenseOAP
dc.titlePrevalence of ocular hypertension and glaucoma in patients with chronic ocular graft-versus-host diseaseen_US
dc.typeJournal Articleen_US
dc.date.updated2017-06-19T01:56:04Z
dc.description.versionAccepted Manuscripten_US
dc.relation.journalGraefe's Archive for Clinical and Experimental Ophthalmologyen_US
dash.depositing.authorDana, Reza
dc.date.available2016
dc.date.available2018-02-23T20:31:37Z
workflow.legacycommentsfile.mismatchen_US
dash.contributor.affiliatedDana, Reza


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