Antigen-specific Treg cells in immunological tolerance: implications for allergic diseases

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Antigen-specific Treg cells in immunological tolerance: implications for allergic diseases

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Title: Antigen-specific Treg cells in immunological tolerance: implications for allergic diseases
Author: Abdel-Gadir, Azza; Massoud, Amir H.; Chatila, Talal A.

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Citation: Abdel-Gadir, Azza, Amir H. Massoud, and Talal A. Chatila. 2018. “Antigen-specific Treg cells in immunological tolerance: implications for allergic diseases.” F1000Research 7 (1): 38. doi:10.12688/f1000research.12650.1. http://dx.doi.org/10.12688/f1000research.12650.1.
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Abstract: Allergic diseases are chronic inflammatory disorders in which there is failure to mount effective tolerogenic immune responses to inciting allergens. The alarming rise in the prevalence of allergic diseases in recent decades has spurred investigations to elucidate the mechanisms of breakdown in tolerance in these disorders and means of restoring it. Tolerance to allergens is critically dependent on the generation of allergen-specific regulatory T (Treg) cells, which mediate a state of sustained non-responsiveness to the offending allergen. In this review, we summarize recent advances in our understanding of mechanisms governing the generation and function of allergen-specific Treg cells and their subversion in allergic diseases. We will also outline approaches to harness allergen-specific Treg cell responses to restore tolerance in these disorders.
Published Version: doi:10.12688/f1000research.12650.1
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765398/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34868722
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