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dc.contributor.authorWang, Sean Ken_US
dc.contributor.authorGuo, Xinxingen_US
dc.contributor.authorXiao, Ouen_US
dc.contributor.authorChen, Yanxianen_US
dc.contributor.authorLiu, Ranen_US
dc.contributor.authorHuang, Wenyongen_US
dc.contributor.authorHe, Mingguangen_US
dc.date.accessioned2018-02-26T20:38:32Z
dc.date.issued2017en_US
dc.identifier.citationWang, Sean K, Xinxing Guo, Ou Xiao, Yanxian Chen, Ran Liu, Wenyong Huang, and Mingguang He. 2017. “Qualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Study.” BMJ Open 7 (12): e017923. doi:10.1136/bmjopen-2017-017923. http://dx.doi.org/10.1136/bmjopen-2017-017923.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34868761
dc.description.abstractBackground/aims To develop a standardised grading scheme, using standard photos, for spectral-domain ocular coherence tomography (SD-OCT) images of the posterior eye and evaluate the interobserver agreement among trained ophthalmologists in identifying pathological changes. Methods: Subjects were recruited from Liwan District, Guangzhou, with SD-OCT data collection from June 2013 to November 2013 as part of 10-year follow-up visits from the Liwan Eye Study. All subjects underwent SD-OCT imaging of the macula with scanning lines analysed by two ophthalmologists to assess for the presence of 12 different posterior segment lesions. Per cent agreement for each lesion between the graders and quantitative measures of dome-shaped macula (DSM) height and choroidal thickness were calculated. Results: A total of 679 SD-OCT images from 679 subjects were independently evaluated by the two graders. Each of the 12 lesions was successfully graded as present or absent in over 96% of images. For all lesions, per cent agreement between observers was over 90%, ranging from 90.7% for epiretinal membranes and retinal pigment epithelium thickenings to 99.7% for full thickness macular holes and retinal detachments. Quantitative measurements of DSM height and choroidal thickness at three locations of the eye all exhibited intraclass correlation scores between the two graders of greater than 0.9. Conclusion: Our study demonstrates high concordance between graders in characterising posterior segment lesions using SD-OCT images, validating the continued use of this imaging modality in the diagnosis of posterior eye disease.en
dc.language.isoen_USen
dc.publisherBMJ Publishing Groupen
dc.relation.isversionofdoi:10.1136/bmjopen-2017-017923en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770917/pdf/en
dash.licenseLAAen_US
dc.subjectoptical coherence tomographyen
dc.subjectposterior segmenten
dc.subjectqualitative gradingen
dc.subjectquantitative measurementen
dc.titleQualitative and quantitative assessment of posterior segment optical coherence tomography images using standard photos: the Liwan Eye Studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMJ Openen
dash.depositing.authorWang, Sean Ken_US
dc.date.available2018-02-26T20:38:32Z
dc.identifier.doi10.1136/bmjopen-2017-017923*
dash.contributor.affiliatedWang, Sean


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