Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair

DSpace/Manakin Repository

Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair

Citable link to this page

 

 
Title: Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair
Author: Schäfer, Frank-Mattias; Algarrahi, Khalid; Savarino, Alyssa; Yang, Xuehui; Seager, Catherine; Franck, Debra; Costa, Kyle; Liu, Shanshan; Logvinenko, Tanya; Adam, Rosalyn; Mauney, Joshua R.

Note: Order does not necessarily reflect citation order of authors.

Citation: Schäfer, F., K. Algarrahi, A. Savarino, X. Yang, C. Seager, D. Franck, K. Costa, et al. 2017. “Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair.” Stem Cell Reports 9 (6): 2005-2017. doi:10.1016/j.stemcr.2017.10.025. http://dx.doi.org/10.1016/j.stemcr.2017.10.025.
Full Text & Related Files:
Abstract: Summary The bladder urothelium functions as a urine-blood barrier and consists of basal, intermediate, and superficial cell populations. Reconstructive procedures such as augmentation cystoplasty and focal mucosal resection involve localized surgical damage to the bladder wall whereby focal segments of the urothelium and underlying submucosa are respectively removed or replaced and regeneration ensues. We demonstrate using lineage-tracing systems that urothelial regeneration following augmentation cystoplasty with acellular grafts exclusively depends on host keratin 5-expressing basal cells to repopulate all lineages of the de novo urothelium at implant sites. Conversely, repair of focal mucosal defects not only employs this mechanism, but in parallel host intermediate cell daughters expressing uroplakin 2 give rise to themselves and are also contributors to superficial cells in neotissues. These results highlight the diversity of urothelial regenerative responses to surgical injury and may lead to advancements in bladder tissue engineering approaches.
Published Version: doi:10.1016/j.stemcr.2017.10.025
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785709/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34868772
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters