CD1a on Langerhans cells controls inflammatory skin diseases

DSpace/Manakin Repository

CD1a on Langerhans cells controls inflammatory skin diseases

Citable link to this page


Title: CD1a on Langerhans cells controls inflammatory skin diseases
Author: Kim, Ji Hyung; Hu, Yu; Yongqing, Tang; Kim, Jessica; Hughes, Victoria A.; Nours, Jérôme Le; Marquez, Elsa A.; Purcell, Anthony W.; Wan, Qi; Sugita, Masahiko; Rossjohn, Jamie; Winau, Florian

Note: Order does not necessarily reflect citation order of authors.

Citation: Kim, J. H., Y. Hu, T. Yongqing, J. Kim, V. A. Hughes, J. L. Nours, E. A. Marquez, et al. 2016. “CD1a on Langerhans cells controls inflammatory skin diseases.” Nature immunology 17 (10): 1159-1166. doi:10.1038/ni.3523.
Full Text & Related Files:
Abstract: CD1a is a lipid-presenting molecule abundantly expressed on Langerhans cells. However, the in vivo role of CD1a remains unclear, principally because CD1a is lacking in mice. Using CD1a-transgenic mice, we show that the plant-derived lipid urushiol triggers CD1a-dependent skin inflammation, driven by CD4+ T cells producing IL-17 and IL-22. Human subjects with poison ivy dermatitis showed a similar cytokine signature following CD1a-mediated urushiol recognition. Among different urushiol congeners, we identified diunsaturated pentadecylcatechol (C15:2) as the dominant antigen for CD1a-restricted T cells. We determined the crystal structure of the CD1a-urushiol (C15:2) complex, demonstrating the molecular basis of urushiol interaction with the antigen-binding cleft of CD1a. In a mouse model and psoriasis patients, CD1a amplified inflammatory responses mediated by TH17 cells reactive with self lipid antigens. Treatment with blocking antibodies against CD1a alleviated skin inflammation. Thus, we propose CD1a as a potential therapeutic target in inflammatory skin diseases.
Published Version: doi:10.1038/ni.3523
Other Sources:
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at
Citable link to this page:
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search