A case of molecularly profiled extraneural medulloblastoma metastases in a child

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A case of molecularly profiled extraneural medulloblastoma metastases in a child

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Title: A case of molecularly profiled extraneural medulloblastoma metastases in a child
Author: Mobark, Nahla Ali; Al-Harbi, Musa; Mosleh, Othman; Santagata, Sandro; Snuderl, Matija; Abedalthagafi, Malak

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Citation: Mobark, Nahla Ali, Musa Al-Harbi, Othman Mosleh, Sandro Santagata, Matija Snuderl, and Malak Abedalthagafi. 2018. “A case of molecularly profiled extraneural medulloblastoma metastases in a child.” BMC Medical Genetics 19 (1): 10. doi:10.1186/s12881-018-0526-8. http://dx.doi.org/10.1186/s12881-018-0526-8.
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Abstract: Background: Extraneural metastases are relatively rare manifestations of medulloblastoma. Case presentation: We present the case of a young boy with group three MYCN-amplified medulloblastoma. He received multimodal chemotherapy consisting of gross total resection followed by postoperative craniospinal radiation and adjuvant chemotherapy. The patient developed extraneural metastases 4 months after the end of therapy. Literature review identifies the poor prognosis of MYCN-amplified medulloblastomas as well as extraneural metastases; we review the current limitations and future directions of medulloblastoma treatment options. Conclusion: To the best of our knowledge, this is the first molecularly characterized report of extraneural metastases of medulloblastoma in a child.
Published Version: doi:10.1186/s12881-018-0526-8
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772742/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34868816
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