Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease
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Author
Chaffin, Mark
Horner, Steven
McMillan, Brian J.
Leed, Alison
Weale, Michael E.
Spencer, Chris C. A.
Aguet, François
Segrè, Ayellet V.
Ardlie, Kristin G.
Kaushik, Virendar K.
Consortium, CARDIoGRAMplusC4D
Kathiresan, Sekar
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https://doi.org/10.1038/ng.3914Metadata
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Klarin, D., Q. M. Zhu, C. A. Emdin, M. Chaffin, S. Horner, B. J. McMillan, A. Leed, et al. 2017. “Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease.” Nature genetics 49 (9): 1392-1397. doi:10.1038/ng.3914. http://dx.doi.org/10.1038/ng.3914.Abstract
UK Biobank is among the world’s largest repositories for phenotypic and genotypic information in individuals of European ancestry1. We performed a genome-wide association study in UK Biobank testing ~9 million DNA sequence variants for association with coronary artery disease (4,831 cases; 115,455 controls) and carried out meta-analysis with previously published results. We identified fifteen novel loci, bringing the total number of coronary artery disease-associated loci to 95. Phenome-wide association scanning revealed that CCDC92 likely affects coronary artery disease through insulin resistance pathways whereas experimental analysis suggests that ARHGEF26 impacts the transendothelial migration of leukocytes.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577383/pdf/Terms of Use
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