Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease

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Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease

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Title: Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease
Author: Klarin, Derek; Zhu, Qiuyu Martin; Emdin, Connor A.; Chaffin, Mark; Horner, Steven; McMillan, Brian J.; Leed, Alison; Weale, Michael E.; Spencer, Chris C. A.; Aguet, François; Segrè, Ayellet V.; Ardlie, Kristin G.; Khera, Amit V.; Kaushik, Virendar K.; Natarajan, Pradeep; Consortium, CARDIoGRAMplusC4D; Kathiresan, Sekar

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Citation: Klarin, D., Q. M. Zhu, C. A. Emdin, M. Chaffin, S. Horner, B. J. McMillan, A. Leed, et al. 2017. “Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease.” Nature genetics 49 (9): 1392-1397. doi:10.1038/ng.3914. http://dx.doi.org/10.1038/ng.3914.
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Abstract: UK Biobank is among the world’s largest repositories for phenotypic and genotypic information in individuals of European ancestry1. We performed a genome-wide association study in UK Biobank testing ~9 million DNA sequence variants for association with coronary artery disease (4,831 cases; 115,455 controls) and carried out meta-analysis with previously published results. We identified fifteen novel loci, bringing the total number of coronary artery disease-associated loci to 95. Phenome-wide association scanning revealed that CCDC92 likely affects coronary artery disease through insulin resistance pathways whereas experimental analysis suggests that ARHGEF26 impacts the transendothelial migration of leukocytes.
Published Version: doi:10.1038/ng.3914
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577383/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34868858
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