Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease
McMillan, Brian J.
Weale, Michael E.
Spencer, Chris C. A.
Segrè, Ayellet V.
Ardlie, Kristin G.
Kaushik, Virendar K.
Kathiresan, SekarNote: Order does not necessarily reflect citation order of authors.
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CitationKlarin, D., Q. M. Zhu, C. A. Emdin, M. Chaffin, S. Horner, B. J. McMillan, A. Leed, et al. 2017. “Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease.” Nature genetics 49 (9): 1392-1397. doi:10.1038/ng.3914. http://dx.doi.org/10.1038/ng.3914.
AbstractUK Biobank is among the world’s largest repositories for phenotypic and genotypic information in individuals of European ancestry1. We performed a genome-wide association study in UK Biobank testing ~9 million DNA sequence variants for association with coronary artery disease (4,831 cases; 115,455 controls) and carried out meta-analysis with previously published results. We identified fifteen novel loci, bringing the total number of coronary artery disease-associated loci to 95. Phenome-wide association scanning revealed that CCDC92 likely affects coronary artery disease through insulin resistance pathways whereas experimental analysis suggests that ARHGEF26 impacts the transendothelial migration of leukocytes.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34868858
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