A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
Menon, Archita Venugopal
Frenette, Paul S.
Pandolfi, Pier Paolo
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CitationGuarnerio, Jlenia, Lourdes Maria Mendez, Noboru Asada, Archita Venugopal Menon, Jacqueline Fung, Kelsey Berry, Paul S. Frenette, Keisuke Ito, and Pier Paolo Pandolfi. 2018. “A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.” Nature Communications 9 (1): 66. doi:10.1038/s41467-017-02427-x. http://dx.doi.org/10.1038/s41467-017-02427-x.
AbstractDisease recurrence after therapy, due to the persistence of resistant leukemic cells, represents a fundamental problem in the treatment of leukemia. Elucidating the mechanisms responsible for the maintenance of leukemic cells, before and after treatment, is therefore critical to identify curative modalities. It has become increasingly clear that cell-autonomous mechanisms are not solely responsible for leukemia maintenance. Here, we report a role for Pml in mesenchymal stem cells (MSCs) in supporting leukemic cells of both CML and AML. Mechanistically, we show that Pml regulates pro-inflammatory cytokines within MSCs, and that this function is critical in sustaining CML-KLS and AML ckit+ leukemic cells non-cell autonomously.
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