Rivastigmine decreases brain damage in HIV patients with mild cognitive deficits

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Rivastigmine decreases brain damage in HIV patients with mild cognitive deficits

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Title: Rivastigmine decreases brain damage in HIV patients with mild cognitive deficits
Author: Perrotta, Gaetano; Bonnier, Guillaume; Meskaldji, Djalel‐Eddine; Romascano, David; Aydarkhanov, Ruslan; Daducci, Alessandro; Simioni, Samanta; Cavassini, Matthias; Metral, Melanie; Lazeyras, François; Meuli, Reto; Krueger, Gunnar; Du Pasquier, Renaud A.; Granziera, Cristina

Note: Order does not necessarily reflect citation order of authors.

Citation: Perrotta, G., G. Bonnier, D. Meskaldji, D. Romascano, R. Aydarkhanov, A. Daducci, S. Simioni, et al. 2017. “Rivastigmine decreases brain damage in HIV patients with mild cognitive deficits.” Annals of Clinical and Translational Neurology 4 (12): 915-920. doi:10.1002/acn3.493. http://dx.doi.org/10.1002/acn3.493.
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Abstract: Abstract Rivastigmine has been shown to improve cognition in HIV+ patients with minor neurocognitive disorders; however, the mechanisms underlying such beneficial effect are currently unknown. To assess whether rivastigmine therapy is associated with decreased brain inflammation and damage, we performed T1/T2* relaxometry and magnetization transfer imaging in 17 aviremic HIV+ patients with minor neurocognitive disorders enrolled on a crossed over randomized rivastigmine trial. Rivastigmine therapy was associated with changes in MRI metrics indicating a decrease in brain water content (i.e., edema reabsorption) and/or reduced demyelination/axonal damage. Furthermore, MRI changes correlated with cognitive improvement on rivastigmine therapy.
Published Version: doi:10.1002/acn3.493
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740253/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34868920
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