dc.contributor.author | Perrotta, Gaetano | en_US |
dc.contributor.author | Bonnier, Guillaume | en_US |
dc.contributor.author | Meskaldji, Djalel‐Eddine | en_US |
dc.contributor.author | Romascano, David | en_US |
dc.contributor.author | Aydarkhanov, Ruslan | en_US |
dc.contributor.author | Daducci, Alessandro | en_US |
dc.contributor.author | Simioni, Samanta | en_US |
dc.contributor.author | Cavassini, Matthias | en_US |
dc.contributor.author | Metral, Melanie | en_US |
dc.contributor.author | Lazeyras, François | en_US |
dc.contributor.author | Meuli, Reto | en_US |
dc.contributor.author | Krueger, Gunnar | en_US |
dc.contributor.author | Du Pasquier, Renaud A. | en_US |
dc.contributor.author | Granziera, Cristina | en_US |
dc.date.accessioned | 2018-02-26T20:41:58Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Perrotta, G., G. Bonnier, D. Meskaldji, D. Romascano, R. Aydarkhanov, A. Daducci, S. Simioni, et al. 2017. “Rivastigmine decreases brain damage in HIV patients with mild cognitive deficits.” Annals of Clinical and Translational Neurology 4 (12): 915-920. doi:10.1002/acn3.493. http://dx.doi.org/10.1002/acn3.493. | en |
dc.identifier.issn | | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:34868920 | |
dc.description.abstract | Abstract Rivastigmine has been shown to improve cognition in HIV+ patients with minor neurocognitive disorders; however, the mechanisms underlying such beneficial effect are currently unknown. To assess whether rivastigmine therapy is associated with decreased brain inflammation and damage, we performed T1/T2* relaxometry and magnetization transfer imaging in 17 aviremic HIV+ patients with minor neurocognitive disorders enrolled on a crossed over randomized rivastigmine trial. Rivastigmine therapy was associated with changes in MRI metrics indicating a decrease in brain water content (i.e., edema reabsorption) and/or reduced demyelination/axonal damage. Furthermore, MRI changes correlated with cognitive improvement on rivastigmine therapy. | en |
dc.language.iso | en_US | en |
dc.publisher | John Wiley and Sons Inc. | en |
dc.relation.isversionof | doi:10.1002/acn3.493 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740253/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | Brief Communication | en |
dc.title | Rivastigmine decreases brain damage in HIV patients with mild cognitive deficits | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Annals of Clinical and Translational Neurology | en |
dash.depositing.author | Granziera, Cristina | en_US |
dc.date.available | 2018-02-26T20:41:58Z | |
dc.identifier.doi | 10.1002/acn3.493 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Granziera, Cristina | |