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dc.contributor.authorPerrotta, Gaetanoen_US
dc.contributor.authorBonnier, Guillaumeen_US
dc.contributor.authorMeskaldji, Djalel‐Eddineen_US
dc.contributor.authorRomascano, Daviden_US
dc.contributor.authorAydarkhanov, Ruslanen_US
dc.contributor.authorDaducci, Alessandroen_US
dc.contributor.authorSimioni, Samantaen_US
dc.contributor.authorCavassini, Matthiasen_US
dc.contributor.authorMetral, Melanieen_US
dc.contributor.authorLazeyras, Françoisen_US
dc.contributor.authorMeuli, Retoen_US
dc.contributor.authorKrueger, Gunnaren_US
dc.contributor.authorDu Pasquier, Renaud A.en_US
dc.contributor.authorGranziera, Cristinaen_US
dc.date.accessioned2018-02-26T20:41:58Z
dc.date.issued2017en_US
dc.identifier.citationPerrotta, G., G. Bonnier, D. Meskaldji, D. Romascano, R. Aydarkhanov, A. Daducci, S. Simioni, et al. 2017. “Rivastigmine decreases brain damage in HIV patients with mild cognitive deficits.” Annals of Clinical and Translational Neurology 4 (12): 915-920. doi:10.1002/acn3.493. http://dx.doi.org/10.1002/acn3.493.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34868920
dc.description.abstractAbstract Rivastigmine has been shown to improve cognition in HIV+ patients with minor neurocognitive disorders; however, the mechanisms underlying such beneficial effect are currently unknown. To assess whether rivastigmine therapy is associated with decreased brain inflammation and damage, we performed T1/T2* relaxometry and magnetization transfer imaging in 17 aviremic HIV+ patients with minor neurocognitive disorders enrolled on a crossed over randomized rivastigmine trial. Rivastigmine therapy was associated with changes in MRI metrics indicating a decrease in brain water content (i.e., edema reabsorption) and/or reduced demyelination/axonal damage. Furthermore, MRI changes correlated with cognitive improvement on rivastigmine therapy.en
dc.language.isoen_USen
dc.publisherJohn Wiley and Sons Inc.en
dc.relation.isversionofdoi:10.1002/acn3.493en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740253/pdf/en
dash.licenseLAAen_US
dc.subjectBrief Communicationen
dc.titleRivastigmine decreases brain damage in HIV patients with mild cognitive deficitsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalAnnals of Clinical and Translational Neurologyen
dash.depositing.authorGranziera, Cristinaen_US
dc.date.available2018-02-26T20:41:58Z
dc.identifier.doi10.1002/acn3.493*
dash.authorsorderedfalse
dash.contributor.affiliatedGranziera, Cristina


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