Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
View/ Open
Author
O’Reilly, Paul F.
Richards, J. Brent
Dupuis, Josée
Ingelsson, Erik
Karasik, David
Pilz, Stefan
Berry, Diane
Kestenbaum, Bryan
Zheng, Jusheng
Luan, Jianan
Sofianopoulou, Eleni
Streeten, Elizabeth A.
Albanes, Demetrius
Lutsey, Pamela L.
Yao, Lu
Tang, Weihong
Econs, Michael J.
Wallaschofski, Henri
Völzke, Henry
Zhou, Ang
Power, Chris
McCarthy, Mark I.
Michos, Erin D.
Boerwinkle, Eric
Weinstein, Stephanie J.
Freedman, Neal D.
Huang, Wen-Yi
Van Schoor, Natasja M.
van der Velde, Nathalie
Groot, Lisette C. P. G. M. de
Enneman, Anke
Cupples, L. Adrienne
Booth, Sarah L.
Vasan, Ramachandran S.
Liu, Ching-Ti
Zhou, Yanhua
Ripatti, Samuli
Ohlsson, Claes
Vandenput, Liesbeth
Lorentzon, Mattias
Eriksson, Johan G.
Shea, M. Kyla
Houston, Denise K.
Kritchevsky, Stephen B.
Liu, Yongmei
Lohman, Kurt K.
Ferrucci, Luigi
Peacock, Munro
Gieger, Christian
Beekman, Marian
Slagboom, Eline
Deelen, Joris
Heemst, Diana van
Kleber, Marcus E.
März, Winfried
de Boer, Ian H.
Wood, Alexis C.
Rotter, Jerome I.
Rich, Stephen S.
Robinson-Cohen, Cassianne
den Heijer, Martin
Jarvelin, Marjo-Riitta
Cavadino, Alana
Joshi, Peter K.
Wilson, James F.
Hayward, Caroline
Lind, Lars
Michaëlsson, Karl
Trompet, Stella
Zillikens, M. Carola
Uitterlinden, Andre G.
Rivadeneira, Fernando
Broer, Linda
Zgaga, Lina
Campbell, Harry
Theodoratou, Evropi
Farrington, Susan M.
Timofeeva, Maria
Dunlop, Malcolm G.
Valdes, Ana M.
Tikkanen, Emmi
Lehtimäki, Terho
Lyytikäinen, Leo-Pekka
Kähönen, Mika
Raitakari, Olli T.
Mikkilä, Vera
Ikram, M. Arfan
Sattar, Naveed
Jukema, J. Wouter
Wareham, Nicholas J.
Langenberg, Claudia
Forouhi, Nita G.
Gundersen, Thomas E.
Khaw, Kay-Tee
Butterworth, Adam S.
Danesh, John
Spector, Timothy
Wang, Thomas J.
Hyppönen, Elina
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1038/s41467-017-02662-2Metadata
Show full item recordCitation
Jiang, X., P. F. O’Reilly, H. Aschard, Y. Hsu, J. B. Richards, J. Dupuis, E. Ingelsson, et al. 2018. “Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.” Nature Communications 9 (1): 260. doi:10.1038/s41467-017-02662-2. http://dx.doi.org/10.1038/s41467-017-02662-2.Abstract
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10−9 at rs8018720 in SEC23A, and P = 1.9×10−14 at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable to GWAS common SNPs is 7.5%, with statistically significant loci explaining 38% of this total. Further investigation identifies signal enrichment in immune and hematopoietic tissues, and clustering with autoimmune diseases in cell-type-specific analysis. Larger studies are required to identify additional common SNPs, and to explore the role of rare or structural variants and gene–gene interactions in the heritability of circulating 25-hydroxyvitamin D levels.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772647/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:34868989
Collections
- HMS Scholarly Articles [17922]
- SPH Scholarly Articles [6362]
Contact administrator regarding this item (to report mistakes or request changes)