Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy
View/ Open
Author
Kirtane, Ameya R.
Abouzid, Omar
Minahan, Daniel
Bensel, Taylor
Selinger, Christian
Bershteyn, Anna
Mazdiyasni, Hormoz
Cleveland, Cody
Rogner, Jaimie
Lee, Young-Ah Lucy
Booth, Lucas
Javid, Farhad
Wu, Sarah J.
Grant, Tyler
Bellinger, Andrew M.
Nikolic, Boris
Hayward, Alison
Wood, Lowell
Eckhoff, Philip A.
Langer, Robert
Traverso, Giovanni
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1038/s41467-017-02294-6Metadata
Show full item recordCitation
Kirtane, A. R., O. Abouzid, D. Minahan, T. Bensel, A. L. Hill, C. Selinger, A. Bershteyn, et al. 2018. “Development of an oral once-weekly drug delivery system for HIV antiretroviral therapy.” Nature Communications 9 (1): 2. doi:10.1038/s41467-017-02294-6. http://dx.doi.org/10.1038/s41467-017-02294-6.Abstract
The efficacy of antiretroviral therapy is significantly compromised by medication non-adherence. Long-acting enteral systems that can ease the burden of daily adherence have not yet been developed. Here we describe an oral dosage form composed of distinct drug–polymer matrices which achieved week-long systemic drug levels of the antiretrovirals dolutegravir, rilpivirine and cabotegravir in a pig. Simulations of viral dynamics and patient adherence patterns indicate that such systems would significantly reduce therapeutic failures and epidemiological modelling suggests that using such an intervention prophylactically could avert hundreds of thousands of new HIV cases. In sum, weekly administration of long-acting antiretrovirals via a novel oral dosage form is a promising intervention to help control the HIV epidemic worldwide.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760734/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:34869019
Collections
- FAS Scholarly Articles [18292]
- HMS Scholarly Articles [17922]
- SPH Scholarly Articles [6362]
Contact administrator regarding this item (to report mistakes or request changes)