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dc.contributor.authorKheirkhah, Ahmad
dc.contributor.authorRahimi Darabad, Raheleh
dc.contributor.authorCruzat, Andrea
dc.contributor.authorHajrasouliha, Amir Reza
dc.contributor.authorWitkin, Deborah
dc.contributor.authorWong, Nadia
dc.contributor.authorDana, Reza
dc.contributor.authorHamrah, Pedram
dc.date.accessioned2018-03-14T15:37:44Z
dc.date.issued2015
dc.identifierQuick submit: 2017-06-18T21:48:57-0400
dc.identifier.citationKheirkhah, Ahmad, Raheleh Rahimi Darabad, Andrea Cruzat, Amir Reza Hajrasouliha, Deborah Witkin, Nadia Wong, Reza Dana, and Pedram Hamrah. 2015. “Corneal Epithelial Immune Dendritic Cell Alterations in Subtypes of Dry Eye Disease: A Pilot In Vivo Confocal Microscopic Study.” Investigative Opthalmology & Visual Science 56 (12) (November 5): 7179. doi:10.1167/iovs.15-17433.en_US
dc.identifier.issn1552-5783en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:34917359
dc.description.abstractPurpose To evaluate density and morphology of corneal epithelial immune dendritic cells (DCs) in different subtypes of dry eye disease (DED) using in vivo confocal microscopy (IVCM). Methods This retrospective study included 59 eyes of 37 patients with DED and 40 eyes of 20 age-matched healthy controls. Based on clinical tests, eyes with DED were categorized into two subtypes: aqueous-deficient (n = 35) and evaporative (n = 24). For all subjects, images of laser scanning in vivo confocal microscopy (IVCM) of the central cornea were analyzed for DC density and DC morphology (DC size, number of dendrites, and DC field). These DC parameters were compared among all dry eye and control groups. Results Compared with the controls, patients with DED had significantly higher DC density, larger DC size, higher number of dendrites, and larger DC field (all P < 0.001). Comparison between aqueous-deficient and evaporative subtypes demonstrated that DC density was significantly higher in aqueous-deficient subtype (189.8 ± 36.9 vs. 58.9 ± 9.4 cells/mm2, P = 0.001). However, there were no significant differences in morphologic parameters between DED subtypes. When aqueous-deficient DED with underlying systemic immune disease (Sjögren's syndrome and graft versus host disease) were compared with nonimmune conditions, the immunologic subgroup showed significantly higher DC density, DC size, and number of dendrites (all P < 0.05). Conclusions Corneal IVCM demonstrated differential changes in DC density and morphologic DC parameters between subtypes of DED. These changes, which reflect the degree of immune activation and inflammation in DED, can be used for clinical practice and endpoints in clinical trials.en_US
dc.language.isoen_USen_US
dc.publisherAssociation for Research in Vision and Ophthalmology (ARVO)en_US
dc.relation.isversionof10.1167/iovs.15-17433en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640475/en_US
dash.licenseLAA
dc.titleCorneal Epithelial Immune Dendritic Cell Alterations in Subtypes of Dry Eye Disease: A Pilot In Vivo Confocal Microscopic Studyen_US
dc.typeJournal Articleen_US
dc.date.updated2017-06-19T01:49:00Z
dc.description.versionVersion of Recorden_US
dc.relation.journalInvestigative Opthalmology & Visual Scienceen_US
dash.depositing.authorDana, Reza
dc.date.available2015
dc.date.available2018-03-14T15:37:44Z
dc.identifier.doi10.1167/iovs.15-17433*
workflow.legacycommentscat.complete oap.needmanen_US
dash.contributor.affiliatedKheirkhah, Ahmad
dash.contributor.affiliatedCruzat, Andrea
dash.contributor.affiliatedDana, Reza


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