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dc.contributor.authorGilman, Jodi M.en_US
dc.contributor.authorRadoman, Milenaen_US
dc.contributor.authorSchuster, Randi M.en_US
dc.contributor.authorPachas, Gladysen_US
dc.contributor.authorAzzouz, Nouren_US
dc.contributor.authorFava, Maurizioen_US
dc.contributor.authorEvins, A. Edenen_US
dc.date.accessioned2018-03-20T15:58:19Z
dc.date.issued2018en_US
dc.identifier.citationGilman, Jodi M., Milena Radoman, Randi M. Schuster, Gladys Pachas, Nour Azzouz, Maurizio Fava, and A. Eden Evins. 2018. “Anterior insula activation during inhibition to smoking cues is associated with ability to maintain tobacco abstinence.” Addictive Behaviors Reports 7 (1): 40-46. doi:10.1016/j.abrep.2018.01.002. http://dx.doi.org/10.1016/j.abrep.2018.01.002.en
dc.identifier.issnen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:35014377
dc.description.abstractRelapse to smoking after initial abstinence is a major clinical challenge with significant public health consequences. At the brain and behavioral level, those who relapse to tobacco smoking have both greater cue-reactivity and lower inhibitory control than those who remain abstinent. Little is known about neural activation during inhibitory control tasks in the presence of drug-related cues. In the current study, tobacco smokers (SMK; n = 22) and non-smoking controls (CON; n = 19) completed a Go/NoGo task involving smoking cues during a functional magnetic resonance imaging (fMRI) scan. Following the scan session, smokers were required to quit smoking, and maintenance of abstinence was evaluated as part of a 12-week smoking cessation trial. We evaluated pre-cessation brain activity during NoGo trials in smokers who were versus were not able to quit smoking. We then compared fMRI and inhibitory control measures between smokers and non-smokers. We did not find differences between SMK and CON in performance or activation to smoking or neutral cues. However, compared to SMK who relapsed, SMK who attained biochemically-validated abstinence at the end of the smoking cessation trial had greater neural activation in the anterior insula during NoGo trials specifically with smoking-related cues. Results indicate that within SMK, decreased inhibitory control activation during direct exposure to drug-related stimuli may be a marker of difficulty quitting and relapse vulnerability.en
dc.language.isoen_USen
dc.publisherElsevieren
dc.relation.isversionofdoi:10.1016/j.abrep.2018.01.002en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805503/pdf/en
dash.licenseLAAen_US
dc.subjectSmoking cessationen
dc.subjectTobaccoen
dc.subjectfMRIen
dc.subjectInsulaen
dc.subjectCueen
dc.subjectRelapseen
dc.subjectAnterior cingulate cortexen
dc.subjectACCen
dc.titleAnterior insula activation during inhibition to smoking cues is associated with ability to maintain tobacco abstinenceen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalAddictive Behaviors Reportsen
dash.depositing.authorGilman, Jodi M.en_US
dc.date.available2018-03-20T15:58:19Z
dc.identifier.doi10.1016/j.abrep.2018.01.002*
dash.contributor.affiliatedSchuster, Randi
dash.contributor.affiliatedFava, Maurizio
dash.contributor.affiliatedPachas, Gladys
dash.contributor.affiliatedGilman, Jodi


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